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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.07.003
|2 doi
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|a pubmed25n0838.xml
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|a (DE-627)NLM251440311
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|a (NLM)26232733
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|a (PII)S1521-6616(15)30007-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Scheible, Kristin M
|e verfasserin
|4 aut
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|a Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 29.02.2016
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Homeostatic T cell proliferation is more robust during human fetal development. In order to understand the relative effect of normal fetal homeostasis and perinatal exposures on CD8+ T cell behavior in PT infants, we characterized umbilical cord blood CD8+ T cells from infants born between 23-42weeks gestation. Subjects were recruited as part of the NHLBI-sponsored Prematurity and Respiratory Outcomes Program. Cord blood from PT infants had fewer naïve CD8+ T cells and lower regulatory CD31 expression on both naïve and effector, independent of prenatal exposures. CD8+ T cell in vitro effector function was greater at younger gestational ages, an effect that was exaggerated in infants with prior inflammatory exposures. These results suggest that CD8+ T cells earlier in gestation have loss of regulatory co-receptor CD31 and greater effector differentiation, which may place PT neonates at unique risk for CD8+ T cell-mediated inflammation and impaired T cell memory formation
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Bronchopulmonary dysplasia
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|a CD8+ T cell
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|a Fetus
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|a Immune dysregulation
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|a Inflammation
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|a Neonatal immunity
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|a Prematurity
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|a Platelet Endothelial Cell Adhesion Molecule-1
|2 NLM
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|a Emo, Jason
|e verfasserin
|4 aut
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|a Yang, Hongmei
|e verfasserin
|4 aut
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1 |
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|a Holden-Wiltse, Jeanne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Straw, Andrew
|e verfasserin
|4 aut
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| 700 |
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|a Huyck, Heidie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Misra, Sara
|e verfasserin
|4 aut
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| 700 |
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|a Topham, David J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ryan, Rita M
|e verfasserin
|4 aut
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| 700 |
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|a Reynolds, Anne Marie
|e verfasserin
|4 aut
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|a Mariani, Thomas J
|e verfasserin
|4 aut
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| 700 |
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|a Pryhuber, Gloria S
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 161(2015), 2 vom: 15. Dez., Seite 65-74
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:161
|g year:2015
|g number:2
|g day:15
|g month:12
|g pages:65-74
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|u http://dx.doi.org/10.1016/j.clim.2015.07.003
|3 Volltext
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