Regulatory B cells in CVID patients fail to suppress multifunctional IFN-γ+ TNF-α+ CD4+ T cells differentiation

Regulatory B cells in CVID patients fail to suppress multifunctional IFN-γ+ TNF-α+ CD4+ T cells differentiation

Copyright © 2015 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 160(2015), 2 vom: 02. Okt., Seite 292-300
1. Verfasser: Vlkova, Marcela (VerfasserIn)
Weitere Verfasser: Ticha, Olga, Nechvatalova, Jana, Kalina, Tomas, Litzman, Jiri, Mauri, Claudia, Blair, Paul A
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't B cell Common variable immunodeficiency (CVID) Cytokine production Flow cytometry T cell Cytokines Tumor Necrosis Factor-alpha Interferon-gamma 82115-62-6
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520 |a Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B cell defects in some CVID patient groups, various abnormalities in cytokine production by T cells in CVID patients are frequently observed. Here, we demonstrate a relationship in the production of pro-inflammatory Th1 cytokines and regulatory B cells producing IL-10 between CVID patients and healthy controls. We describe CD19(+)CD24(hi)CD38(hi)IL-10(+) regulatory B cells generated after T cell stimulation of human peripheral blood lymphocytes ex vivo are able to suppress IFN-γ(+)TNF-α(+) producing CD4(+) T cells. This process is impaired in CVID patients, who present with both low numbers of CD19(+)CD24(hi)CD38(hi)IL-10(+) B cells and increased numbers of IFN-γ(+)TNF-α(+)CD4(+) T cells. Disruption of the regulatory B cell response to T cell stimulation explains the excessive T cell activation regarded as an immunoregulatory abnormality that is a frequent finding in CVID patients 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a B cell 
650 4 |a Common variable immunodeficiency (CVID) 
650 4 |a Cytokine production 
650 4 |a Flow cytometry 
650 4 |a T cell 
650 7 |a Cytokines  |2 NLM 
650 7 |a Tumor Necrosis Factor-alpha  |2 NLM 
650 7 |a Interferon-gamma  |2 NLM 
650 7 |a 82115-62-6  |2 NLM 
700 1 |a Ticha, Olga  |e verfasserin  |4 aut 
700 1 |a Nechvatalova, Jana  |e verfasserin  |4 aut 
700 1 |a Kalina, Tomas  |e verfasserin  |4 aut 
700 1 |a Litzman, Jiri  |e verfasserin  |4 aut 
700 1 |a Mauri, Claudia  |e verfasserin  |4 aut 
700 1 |a Blair, Paul A  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 160(2015), 2 vom: 02. Okt., Seite 292-300  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:160  |g year:2015  |g number:2  |g day:02  |g month:10  |g pages:292-300 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2015.06.013  |3 Volltext 
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