Chronic obstructive pulmonary disease induced by exposure to biomass smoke is associated with a Th2 cytokine production profile
Copyright © 2015 Elsevier Inc. All rights reserved.
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 161(2015), 2 vom: 07. Dez., Seite 150-5 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2015
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Biomass smoke COPD Cigarette smoke Cytokines T helper cells Smoke Interleukin-4 207137-56-2 |
| Zusammenfassung: | Copyright © 2015 Elsevier Inc. All rights reserved. Smoking and exposure to biomass smoke induce the release of pro-inflammatory mediators and the activation of T helper cells. The resulting inflammatory response contributes to the development of COPD. Clinical heterogeneity exists among COPD patients, particularly between patients with disease associated with tobacco smoking (TS-COPD) and those exposed to biomass smoke (BE-COPD). The aim of this study was to identify whether exposure to tobacco and biomass smokes promotes different Th responses that contribute to clinical variability. The study only included women. The frequency of Th17 cells in patients with TS-COPD was significantly higher than in patients with BE-COPD and healthy controls (HC). In contrast, patients with BE-COPD had higher levels of Th2 cells than TS-COPD and HC. In accordance, IL-4 serum concentration was higher in BE-COPD than in TS-COPD. Our data indicates that the different responses induced by these two irritants may underlie the clinical heterogeneity between TS- and BE-COPD patients |
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| Beschreibung: | Date Completed 29.02.2016 Date Revised 27.11.2024 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2015.07.009 |