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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201501502
|2 doi
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|a pubmed24n0837.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Liu, Ya
|e verfasserin
|4 aut
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| 245 |
1 |
2 |
|a A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy
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| 264 |
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|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 06.06.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Novel core-shell tumor-penetrating vesicles consisting of a nanovesicle core with tumor-penetrating ligands and enzymatically degradable polymeric peptides anchored covalently to the core to form a thin polymeric shell are evaluated as drug-delivery systems. This delivery platform demonstrates an enhanced therapeutic efficacy attributed to the synergistic contributions from matrix metalloproteinase (MMP)-responsive drug release as well as improved tumor accumulation and penetration in the tumor microenvironment
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| 650 |
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a drug delivery
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| 650 |
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|a peptides
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| 650 |
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|a polymers
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| 650 |
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4 |
|a self-assembly
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| 650 |
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7 |
|a Cell-Penetrating Peptides
|2 NLM
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| 650 |
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7 |
|a Drug Carriers
|2 NLM
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| 650 |
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7 |
|a Oligopeptides
|2 NLM
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| 650 |
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7 |
|a arginyl-glycyl-aspartic acid
|2 NLM
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| 650 |
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|a 78VO7F77PN
|2 NLM
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| 700 |
1 |
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|a Zhang, Di
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qiao, Zeng-Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qi, Guo-Bin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liang, Xing-Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xi-Guang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Hao
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 27(2015), 34 vom: 09. Sept., Seite 5034-42
|w (DE-627)NLM098206397
|x 1521-4095
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|g volume:27
|g year:2015
|g number:34
|g day:09
|g month:09
|g pages:5034-42
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