Suppressing mutation-induced protein aggregation in mammalian cells by mutating residues significantly displaced upon the original mutation
Mutations introduced to wild-type proteins naturally, or intentionally via protein engineering, often lead to protein aggregation. In particular, protein aggregation within mammalian cells has significant implications in the disease pathology and biologics production; making protein aggregation modu...
| Veröffentlicht in: | Biochemical engineering journal. - 1998. - 91(2014) vom: 15. Okt., Seite 196-203 |
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| Format: | Aufsatz |
| Sprache: | English |
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2014
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| Zugriff auf das übergeordnete Werk: | Biochemical engineering journal |
| Schlagworte: | Journal Article mammalian cells mutation protein aggregation protein engineering superoxide dismutase |