Conformation of the Poly(ethylene Glycol) Chains in DiPEGylated Hemoglobin Specifically Probed by SANS : Correlation with PEG Length and in Vivo Efficiency

Cell-free hemoglobin (Hb)-based oxygen carriers have long been proposed as blood substitutes but their clinical use remains tricky due to problems of inefficiency and/or toxicity. Conjugation of Hb with the biocompatible polymer poly(ethylene glycol) (PEG) greatly improved their performance. However...

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Publié dans:Langmuir : the ACS journal of surfaces and colloids. - 1985. - 31(2015), 30 vom: 04. Aug., Seite 8402-10
Auteur principal: Le Cœur, Clémence (Auteur)
Autres auteurs: Combet, Sophie, Carrot, Géraldine, Busch, Peter, Teixeira, José, Longeville, Stéphane
Format: Article en ligne
Langue:English
Publié: 2015
Accès à la collection:Langmuir : the ACS journal of surfaces and colloids
Sujets:Journal Article Research Support, Non-U.S. Gov't Hemoglobins Polyethylene Glycols 3WJQ0SDW1A