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20231224160234.0 |
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cr uuu---uuuuu |
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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.06.014
|2 doi
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|a pubmed24n0835.xml
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|a (DE-627)NLM250633744
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|a (NLM)26148903
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|a (PII)S1521-6616(15)30002-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Thanei, Sophia
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Anti-C1q autoantibodies from systemic lupus erythematosus patients activate the complement system via both the classical and lectin pathways
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|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.12.2015
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|a Date Revised 24.09.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Autoantibodies against complement C1q (anti-C1q) strongly correlate with the occurrence of lupus nephritis and hypocomplementemia in systemic lupus erythematosus (SLE). Although a direct pathogenic role of anti-C1q has been suggested, the assumed complement-activating capacity remains to be elucidated. Using an ELISA-based assay, we found that anti-C1q activate the classical (CP) and lectin pathways (LP) depending on the anti-C1q immunoglobulin-class repertoire present in the patient's serum. IgG anti-C1q resulted in the activation of the CP as reflected by C4b deposition in the presence of purified C1 and C4 in a dose-dependent manner. The extent of C4b deposition correlated with anti-C1q levels in SLE patients but not in healthy controls. Our data indicate that SLE patient-derived anti-C1q can activate the CP and the LP but not the alternative pathway of complement. These findings are of importance for the understanding of the role of anti-C1q in SLE suggesting a direct link to hypocomplementemia
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Anti-C1q
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|a Classical pathway
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| 650 |
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|a Complement
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|a Lectin pathway
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| 650 |
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|a Lupus nephritis
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| 650 |
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|a Systemic lupus erythematosus
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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|a Immunoglobulin A
|2 NLM
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| 650 |
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|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a Complement C1q
|2 NLM
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| 650 |
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|a 80295-33-6
|2 NLM
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| 700 |
1 |
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|a Vanhecke, Dominique
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Trendelenburg, Marten
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 160(2015), 2 vom: 07. Okt., Seite 180-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:160
|g year:2015
|g number:2
|g day:07
|g month:10
|g pages:180-7
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.06.014
|3 Volltext
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|a SYSFLAG_A
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|a GBV_ILN_11
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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|d 160
|j 2015
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