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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1107/S1600577515006001
|2 doi
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|a pubmed25n0835.xml
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|a (NLM)26134810
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Murrie, Rhiannon P
|e verfasserin
|4 aut
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| 245 |
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|a Live small-animal X-ray lung velocimetry and lung micro-tomography at the Australian Synchrotron Imaging and Medical Beamline
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|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 11.04.2016
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|a Date Revised 25.11.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The high flux and coherence produced at long synchrotron beamlines makes them well suited to performing phase-contrast X-ray imaging of the airways and lungs of live small animals. Here, findings of the first live-animal imaging on the Imaging and Medical Beamline (IMBL) at the Australian Synchrotron are reported, demonstrating the feasibility of performing dynamic lung motion measurement and high-resolution micro-tomography. Live anaesthetized mice were imaged using 30 keV monochromatic X-rays at a range of sample-to-detector propagation distances. A frame rate of 100 frames s(-1) allowed lung motion to be determined using X-ray velocimetry. A separate group of humanely killed mice and rats were imaged by computed tomography at high resolution. Images were reconstructed and rendered to demonstrate the capacity for detailed, user-directed display of relevant respiratory anatomy. The ability to perform X-ray velocimetry on live mice at the IMBL was successfully demonstrated. High-quality renderings of the head and lungs visualized both large structures and fine details of the nasal and respiratory anatomy. The effect of sample-to-detector propagation distance on contrast and resolution was also investigated, demonstrating that soft tissue contrast increases, and resolution decreases, with increasing propagation distance. This new capability to perform live-animal imaging and high-resolution micro-tomography at the IMBL enhances the capability for investigation of respiratory diseases and the acceleration of treatment development in Australia
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4 |
|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a X-ray
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| 650 |
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4 |
|a lung
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| 650 |
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4 |
|a microtomography
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| 650 |
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4 |
|a phase contrast
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| 650 |
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4 |
|a velocimetry
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| 700 |
1 |
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|a Morgan, Kaye S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maksimenko, Anton
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fouras, Andreas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Paganin, David M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hall, Chris
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Siu, Karen K W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Parsons, David W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Donnelley, Martin
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 22(2015), 4 vom: 02. Juli, Seite 1049-55
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnas
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| 773 |
1 |
8 |
|g volume:22
|g year:2015
|g number:4
|g day:02
|g month:07
|g pages:1049-55
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| 856 |
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|u http://dx.doi.org/10.1107/S1600577515006001
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