|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM250511835 |
| 003 |
DE-627 |
| 005 |
20250218183539.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2015 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1107/S1600577515005627
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0835.xml
|
| 035 |
|
|
|a (DE-627)NLM250511835
|
| 035 |
|
|
|a (NLM)26134804
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Novikova, Natalia
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Distinct effect of xenobiotics on the metal-binding properties of protein molecules
|
| 264 |
|
1 |
|c 2015
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 11.04.2016
|
| 500 |
|
|
|a Date Revised 03.07.2015
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a The X-ray standing-wave method was applied to study the elemental composition and molecular organization of ordered protein films of alkaline phosphatase exposed to different xenobiotics (drug compounds, lead). Binding of metal ions from triply distilled water to protein molecules has been experimentally observed. Definite differences in the arrangement of impurity metal ions in the films have been established. The considerable enhancement of protein-metal interactions is attributed to partial rearrangement of the protein native structure, induced by xenobiotics
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Langmuir–Blodgett monolayer
|
| 650 |
|
4 |
|a X-ray fluorescence
|
| 650 |
|
4 |
|a X-ray total external reflection
|
| 650 |
|
4 |
|a alkaline phosphatase
|
| 650 |
|
4 |
|a chelating drug compounds
|
| 650 |
|
4 |
|a trace metal binding
|
| 650 |
|
7 |
|a Metals
|2 NLM
|
| 650 |
|
7 |
|a Proteins
|2 NLM
|
| 650 |
|
7 |
|a Xenobiotics
|2 NLM
|
| 700 |
1 |
|
|a Kovalchuk, Mikhail
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Stepina, Nina
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gaynutdinov, Radmir
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chukhrai, Elena
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yurieva, Eleonora
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 22(2015), 4 vom: 02. Juli, Seite 1001-7
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnns
|
| 773 |
1 |
8 |
|g volume:22
|g year:2015
|g number:4
|g day:02
|g month:07
|g pages:1001-7
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1107/S1600577515005627
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_40
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_2005
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 22
|j 2015
|e 4
|b 02
|c 07
|h 1001-7
|