Compromised immune response in infants at risk for type 1 diabetes born by Caesarean Section

Compromised immune response in infants at risk for type 1 diabetes born by Caesarean Section

Copyright © 2015 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 160(2015), 2 vom: 26. Okt., Seite 282-5
1. Verfasser: Puff, R (VerfasserIn)
Weitere Verfasser: D'Orlando, O, Heninger, A-K, Kühn, D, Krause, S, Winkler, C, Beyerlein, A, Bonifacio, E, Ziegler, A-G
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Caesarean Section Cytokine Immune responsiveness Tetanus response Type 1 diabetes Antibodies, Bacterial CXCL8 protein, human IL10 protein, human mehr... IL1B protein, human IL2 protein, human IL6 protein, human Immunoglobulin G Interleukin-1beta Interleukin-2 Interleukin-6 Interleukin-8 Tetanus Toxin Tetanus Toxoid Tumor Necrosis Factor-alpha Interleukin-10 130068-27-8 Interleukin-12 187348-17-0 Interferon-gamma 82115-62-6 Granulocyte-Macrophage Colony-Stimulating Factor 83869-56-1
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100 1 |a Puff, R  |e verfasserin  |4 aut 
245 1 0 |a Compromised immune response in infants at risk for type 1 diabetes born by Caesarean Section 
264 1 |c 2015 
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500 |a Date Completed 15.12.2015 
500 |a Date Revised 16.08.2019 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2015 Elsevier Inc. All rights reserved. 
520 |a Children born by Caesarean Section have a higher risk for type 1 diabetes. We aimed to investigate whether Caesarean Section leads to alterations of the immune response in children with familial risk for type 1 diabetes. We examined measures of innate and adaptive immune responses in 94 prospectively followed children, including 40 born by Caesarean Section. Proinflammatory serum cytokine concentrations were determined at age 6 months. As a measure of vaccine response, IgG1, IgG2, and IgG4 tetanus antibody titers and CD4(+) T cell proliferation against tetanus toxoid were quantified. Compared to infants born by vaginal delivery, infants born by Caesarean Section had lower concentrations of the cytokines IFN-ɣ (p=0.014) and IL-8 (p=0.005), and weaker CD4(+) T cell responses to tetanus measured in the first (p=0.007) and second year (p=0.047) of life. Overall, our findings provide evidence that the mode of delivery influences the immune status and responsiveness during childhood 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Caesarean Section 
650 4 |a Cytokine 
650 4 |a Immune responsiveness 
650 4 |a Tetanus response 
650 4 |a Type 1 diabetes 
650 7 |a Antibodies, Bacterial  |2 NLM 
650 7 |a CXCL8 protein, human  |2 NLM 
650 7 |a IL10 protein, human  |2 NLM 
650 7 |a IL1B protein, human  |2 NLM 
650 7 |a IL2 protein, human  |2 NLM 
650 7 |a IL6 protein, human  |2 NLM 
650 7 |a Immunoglobulin G  |2 NLM 
650 7 |a Interleukin-1beta  |2 NLM 
650 7 |a Interleukin-2  |2 NLM 
650 7 |a Interleukin-6  |2 NLM 
650 7 |a Interleukin-8  |2 NLM 
650 7 |a Tetanus Toxin  |2 NLM 
650 7 |a Tetanus Toxoid  |2 NLM 
650 7 |a Tumor Necrosis Factor-alpha  |2 NLM 
650 7 |a Interleukin-10  |2 NLM 
650 7 |a 130068-27-8  |2 NLM 
650 7 |a Interleukin-12  |2 NLM 
650 7 |a 187348-17-0  |2 NLM 
650 7 |a Interferon-gamma  |2 NLM 
650 7 |a 82115-62-6  |2 NLM 
650 7 |a Granulocyte-Macrophage Colony-Stimulating Factor  |2 NLM 
650 7 |a 83869-56-1  |2 NLM 
700 1 |a D'Orlando, O  |e verfasserin  |4 aut 
700 1 |a Heninger, A-K  |e verfasserin  |4 aut 
700 1 |a Kühn, D  |e verfasserin  |4 aut 
700 1 |a Krause, S  |e verfasserin  |4 aut 
700 1 |a Winkler, C  |e verfasserin  |4 aut 
700 1 |a Beyerlein, A  |e verfasserin  |4 aut 
700 1 |a Bonifacio, E  |e verfasserin  |4 aut 
700 1 |a Ziegler, A-G  |e verfasserin  |4 aut 
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