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231224s2015 xx |||||o 00| ||eng c |
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|a 10.5713/ajas.14.0784
|2 doi
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|a pubmed24n0834.xml
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|a eng
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|a Han, Haoyuan
|e verfasserin
|4 aut
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|a Y-Single Nucleotide Polymorphisms Diversity in Chinese Indigenous Horse
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a Date Completed 24.06.2015
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|a Date Revised 30.09.2020
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|a published: Print
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|a Citation Status PubMed-not-MEDLINE
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|a In contrast to high genetic diversity of mitochondrial DNA (mtDNA), equine Y chromosome shows extremely low variability, implying limited patrilines in the domesticated horse. In this study, we applied direct sequencing and restriction fragment length polymorphism (RFLP) methods to investigate the polymorphisms of 33 Y chromosome specific loci in 304 Chinese indigenous horses from 13 breeds. Consequently, two Y-single nucleotide polymorphisms (SNPs) (Y-45701/997 and Y-50869) and one Y-indel (Y-45288) were identified. Of those, the Y-50869 (T>A) revealed the highest variation frequency (24.67%), whereas it was only 3.29% and 1.97% in Y-45288 (T/-) and Y-45701/997 (G>T) locus, respectively. These three mutations accounted for 27.96% of the total samples and identified five Y-SNP haplotypes, demonstrating genetic diversity of Y chromosome in Chinese horses. In addition, all the five Y-SNP haplotypes were shared by different breeds. Among 13 horse breeds analyzed, Balikun horse displayed the highest nucleotide diversity (π = 5.6×10(-4)) and haplotype diversity (h = 0.527), while Ningqiang horse showed the lowest nucleotide diversity (π = 0.00000) and haplotype diversity (h = 0.000). The results also revealed that Chinese horses had a different polymorphic pattern of Y chromosome from European and American horses. In conclusion, Chinese horses revealed genetic diversity of Y chromosome, however more efforts should be made to better understand the domestication and paternal origin of Chinese indigenous horses
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|a Journal Article
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|a Chinese Indigenous Horse
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| 650 |
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|a Diversity
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|a Single Nucleotide Polymorphisms
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| 650 |
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|a Y Chromosome
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| 700 |
1 |
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|a Zhang, Qin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Kexin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yue, Xiangpeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dang, Ruihua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lan, Xianyong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Hong
|e verfasserin
|4 aut
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| 700 |
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|a Lei, Chuzhao
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Asian-Australasian journal of animal sciences
|d 1998
|g 28(2015), 8 vom: 24. Aug., Seite 1066-74
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|x 1011-2367
|7 nnns
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| 773 |
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|g volume:28
|g year:2015
|g number:8
|g day:24
|g month:08
|g pages:1066-74
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|u http://dx.doi.org/10.5713/ajas.14.0784
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