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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.06.005
|2 doi
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|a pubmed24n0834.xml
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|a (NLM)26101092
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|a (PII)S1521-6616(15)00207-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Shimizu, Masaki
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis
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|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 15.12.2015
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|a Date Revised 10.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a To assess the role of IL-6/IL-18 in the pathogenesis of systemic juvenile idiopathic arthritis (s-JIA) and to investigate the clinical significance of serum IL-18 levels for predicting macrophage activation syndrome (MAS) development, we measured the serum IL-6/IL-18 levels in 76s-JIA patients, including 15 with MAS, and compared them with the clinical features. We identified 2 distinct subsets on the basis of serum IL-6/IL-18 levels. The IL-18-dominant subset had more patients who developed MAS. Serum IL-18 levels during active phase in patients with MAS were significantly higher than those without MAS. The cutoff value of serum IL-18 levels for predicting MAS development was 47750 pg/ml. The patients with IL-18 dominant subset at their disease onset were significantly more likely to develop MAS after TCZ therapy started. IL-18 might have a key role in the pathogenesis of MAS. Serum IL-18 levels >47750 pg/ml might be useful to predict MAS development
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|a Journal Article
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| 650 |
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|a Interleukin-18 (IL-18)
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| 650 |
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|a Prediction of macrophage activation syndrome
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| 650 |
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4 |
|a Systemic juvenile idiopathic arthritis
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| 650 |
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7 |
|a IL6 protein, human
|2 NLM
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| 650 |
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|a Interleukin-18
|2 NLM
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| 650 |
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7 |
|a Interleukin-6
|2 NLM
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| 700 |
1 |
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|a Nakagishi, Yasuo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Inoue, Natsumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mizuta, Mao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ko, Giyo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Saikawa, Yutaka
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kubota, Tomohiro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yamasaki, Yuichi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Takei, Syuji
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yachie, Akihiro
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 160(2015), 2 vom: 14. Okt., Seite 277-81
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:160
|g year:2015
|g number:2
|g day:14
|g month:10
|g pages:277-81
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.06.005
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