Morphological Versatility in the Self-Assembly of Val-Ala and Ala-Val Dipeptides

Since the discovery of dipeptide self-assembly, diphenylalanine (Phe-Phe)-based dipeptides have been widely investigated in a variety of fields. Although various supramolecular Phe-Phe-based structures including tubes, vesicles, fibrils, sheets, necklaces, flakes, ribbons, and wires have been demons...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 31(2015), 26 vom: 07. Juli, Seite 7337-45
1. Verfasser: Erdogan, Hakan (VerfasserIn)
Weitere Verfasser: Babur, Esra, Yilmaz, Mehmet, Candas, Elif, Gordesel, Merve, Dede, Yavuz, Oren, Ersin Emre, Demirel, Gokcen Birlik, Ozturk, Mustafa Kemal, Yavuz, Mustafa Selman, Demirel, Gokhan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Dipeptides Pyridines phenylalanylphenylalanine 2577-40-4 2-Propanol ND2M416302 pyridine NH9L3PP67S
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520 |a Since the discovery of dipeptide self-assembly, diphenylalanine (Phe-Phe)-based dipeptides have been widely investigated in a variety of fields. Although various supramolecular Phe-Phe-based structures including tubes, vesicles, fibrils, sheets, necklaces, flakes, ribbons, and wires have been demonstrated by manipulating the external physical or chemical conditions applied, studies of the morphological diversity of dipeptides other than Phe-Phe are still required to understand both how these small molecules respond to external conditions such as the type of solvent and how the peptide sequence affects self-assembly and the corresponding molecular structures. In this work, we investigated the self-assembly of valine-alanine (Val-Ala) and alanine-valine (Ala-Val) dipeptides by varying the solvent medium. It was observed that Val-Ala dipeptide molecules may generate unique self-assembly-based morphologies in response to the solvent medium used. Interestingly, when Ala-Val dipeptides were utilized as a peptide source instead of Val-Ala, we observed distinct differences in the final dipeptide structures. We believe that such manipulation may not only provide us with a better understanding of the fundamentals of the dipeptide self-assembly process but also may enable us to generate novel peptide-based materials for various applications 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a phenylalanylphenylalanine  |2 NLM 
650 7 |a 2577-40-4  |2 NLM 
650 7 |a 2-Propanol  |2 NLM 
650 7 |a ND2M416302  |2 NLM 
650 7 |a pyridine  |2 NLM 
650 7 |a NH9L3PP67S  |2 NLM 
700 1 |a Babur, Esra  |e verfasserin  |4 aut 
700 1 |a Yilmaz, Mehmet  |e verfasserin  |4 aut 
700 1 |a Candas, Elif  |e verfasserin  |4 aut 
700 1 |a Gordesel, Merve  |e verfasserin  |4 aut 
700 1 |a Dede, Yavuz  |e verfasserin  |4 aut 
700 1 |a Oren, Ersin Emre  |e verfasserin  |4 aut 
700 1 |a Demirel, Gokcen Birlik  |e verfasserin  |4 aut 
700 1 |a Ozturk, Mustafa Kemal  |e verfasserin  |4 aut 
700 1 |a Yavuz, Mustafa Selman  |e verfasserin  |4 aut 
700 1 |a Demirel, Gokhan  |e verfasserin  |4 aut 
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773 1 8 |g volume:31  |g year:2015  |g number:26  |g day:07  |g month:07  |g pages:7337-45 
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