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01000naa a22002652 4500 |
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NLM250012219 |
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DE-627 |
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20231224154823.0 |
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cr uuu---uuuuu |
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231224s2015 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2015.06.004
|2 doi
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2 |
|a pubmed24n0833.xml
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|a (DE-627)NLM250012219
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|a (NLM)26079949
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|a (PII)S1521-6616(15)00206-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Cantó, Ester
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction
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1 |
|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 15.12.2015
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|a Date Revised 10.12.2019
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|a published: Print-Electronic
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|a CommentIn: Clin Immunol. 2015 Dec;161(2):354. - PMID 26477483
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Increasing evidence points to a role for chitinase 3-like 1 (CHI3L1) in multiple sclerosis (MS). Here, we aimed to explore the potential involvement of CHI3L1 in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). EAE was induced by immunization with MOG 35-55 peptide in wild-type (WT) and knock-out (KO) mice for breast regression protein 39 (BRP-39), the mouse homologue of human CHI3L1. Immunological responses in splenocytes were assessed by means of polyclonal and antigen-specific proliferation assays. Central nervous system pathology and chitinase gene expression were also investigated. BRP-39 expression was increased in WT MOG 35-55-immunized mice compared to saline-immunized controls. No differences were found between WT and BRP-39 KO mice regarding EAE clinical course, day of disease onset, mortality rate, splenocyte proliferative responses or histopathological findings. These results do not support a role of BRP-39 in the pathogenesis of EAE
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a BRP-39
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| 650 |
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4 |
|a EAE
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| 650 |
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4 |
|a Multiple sclerosis
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| 650 |
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7 |
|a Chil1 protein, mouse
|2 NLM
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| 650 |
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|a Chitinase-3-Like Protein 1
|2 NLM
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| 650 |
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7 |
|a Glycoproteins
|2 NLM
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| 650 |
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7 |
|a Lectins
|2 NLM
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| 650 |
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7 |
|a Myelin-Oligodendrocyte Glycoprotein
|2 NLM
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| 650 |
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7 |
|a Peptide Fragments
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a myelin oligodendrocyte glycoprotein (35-55)
|2 NLM
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| 650 |
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7 |
|a Hexosaminidases
|2 NLM
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| 650 |
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7 |
|a EC 3.2.1.-
|2 NLM
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| 650 |
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7 |
|a chitotriosidase
|2 NLM
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| 650 |
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7 |
|a EC 3.2.1.-
|2 NLM
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| 650 |
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7 |
|a AMCase, mouse
|2 NLM
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| 650 |
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7 |
|a EC 3.2.1.14
|2 NLM
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| 650 |
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7 |
|a Chitinases
|2 NLM
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| 650 |
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7 |
|a EC 3.2.1.14
|2 NLM
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| 650 |
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7 |
|a Chil3 protein, mouse
|2 NLM
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| 650 |
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7 |
|a EC 3.2.1.52
|2 NLM
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| 650 |
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7 |
|a beta-N-Acetylhexosaminidases
|2 NLM
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| 650 |
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7 |
|a EC 3.2.1.52
|2 NLM
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| 700 |
1 |
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|a Espejo, Carmen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Costa, Carme
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Montalban, Xavier
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Comabella, Manuel
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 160(2015), 2 vom: 30. Okt., Seite 133-41
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:160
|g year:2015
|g number:2
|g day:30
|g month:10
|g pages:133-41
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2015.06.004
|3 Volltext
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|a SYSFLAG_A
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 160
|j 2015
|e 2
|b 30
|c 10
|h 133-41
|