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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b01018
|2 doi
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|a pubmed24n0833.xml
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|a (DE-627)NLM249943379
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|a (NLM)26072918
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Gao, Huichang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Effective Spatial Separation of PC12 and NIH3T3 Cells by the Microgrooved Surface of Biocompatible Polymer Substrates
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 11.03.2016
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|a Date Revised 03.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Most organs and tissues are composed of more than one type of cell that is spatially separated and located in different regions. This study used a microgrooved poly(lactic-co-glycolic acid) (PLGA) substrate to guide two types of cocultured cells to two spatially separated regions. Specifically, PC12 pheochromocytoma cells are guided to the inside of microgrooves, whereas NIH3T3 fibroblasts are guided to the ridge area in between neighboring parallel microgrooves. In addition, the microgrooved structures can significantly promote the proliferation and neural differentiation of PC12 cells as well as the osteogenic differentiation of NIH3T3 cells. Therefore, the microgrooved PLGA surface with separated PC12 and NIH3T3 cells can serve as a potential model system for studying nerve reconstruction in bone-repairing scaffolds
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Biocompatible Materials
|2 NLM
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|a Polymers
|2 NLM
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|a Polylactic Acid-Polyglycolic Acid Copolymer
|2 NLM
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|a 1SIA8062RS
|2 NLM
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|a Polyglycolic Acid
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|a 26009-03-0
|2 NLM
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|a Lactic Acid
|2 NLM
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|a 33X04XA5AT
|2 NLM
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| 700 |
1 |
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|a Dong, Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cao, Xiaodong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Xiaoling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Ye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mao, Chuanbin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yingjun
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 31(2015), 24 vom: 23. Juni, Seite 6797-806
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:31
|g year:2015
|g number:24
|g day:23
|g month:06
|g pages:6797-806
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|u http://dx.doi.org/10.1021/acs.langmuir.5b01018
|3 Volltext
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