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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b00874
|2 doi
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|a pubmed24n0831.xml
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|a (DE-627)NLM249534983
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|a (NLM)26030714
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Joseph, Sonja
|e verfasserin
|4 aut
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|a Stability of the Metastable α-Polymorph in Solid Triglyceride Drug-Carrier Nanoparticles
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.03.2016
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|a Date Revised 23.06.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Colloidal dispersions of crystalline nonpolar lipids are under intensive investigation as carrier systems in pharmaceutics and nutrition. In this context, the controlled preparation of particles in a metastable polymorphic state is of some interest for the delivery of active substances. In the present study, tristearin particles stabilized with three α-polymorph-preserving emulsifier regimes ((I) sodium glycocholate/saturated long-chain phospholipids, (II) sodium glycocholate, and (III) poly(vinyl alcohol) (PVA)) were investigated concerning the stability of the metastable α-polymorph after controlled crystallization of the particles from the melt. Upon long-term storage, the α-polymorph was preserved best in PVA-stabilized dispersions, followed by those stabilized with the glycocholate/phospholipid mixture and finally those stabilized solely with the bile salt. In particular for rapidly crystallized nanoparticles, the formation of an α-polymorph with highly reduced lamellarity was observed. According to time-/temperature-resolved synchrotron X-ray diffraction analysis with simultaneous DSC (differential scanning calorimetry) studies, this less-ordered α-polymorph transformed into the common, lamellar α-form upon heating. Although the presence of the less-ordered form is probably related to the extraordinarily high stability of the metastable α-polymorph observed in some of the dispersions, it could not completely prevent the transition into the stable β-polymorph. The higher the transition temperature of the less-ordered α-form to the ordered one, the slower was the polymorphic transition to the stable β-polymorph. To estimate the polymorphic stability of the differently stabilized particles upon isothermal long-term storage, standard DSC measurements on samples stored at 23 °C for 4 weeks seem to be of predictive value
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Drug Carriers
|2 NLM
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|a Phospholipids
|2 NLM
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|a Triglycerides
|2 NLM
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|a Polyvinyl Alcohol
|2 NLM
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|a 9002-89-5
|2 NLM
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|a Glycocholic Acid
|2 NLM
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| 650 |
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|a G59NX3I3RT
|2 NLM
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|a Rappolt, Michael
|e verfasserin
|4 aut
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|a Schoenitz, Martin
|e verfasserin
|4 aut
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|a Huzhalska, Vera
|e verfasserin
|4 aut
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|a Augustin, Wolfgang
|e verfasserin
|4 aut
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|a Scholl, Stephan
|e verfasserin
|4 aut
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|a Bunjes, Heike
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 31(2015), 24 vom: 23. Juni, Seite 6663-74
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:31
|g year:2015
|g number:24
|g day:23
|g month:06
|g pages:6663-74
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|u http://dx.doi.org/10.1021/acs.langmuir.5b00874
|3 Volltext
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