Plasma N-terminal pro-B-type natriuretic peptide concentration in healthy retired racing Greyhounds
© 2015 American Society for Veterinary Clinical Pathology.
| Publié dans: | Veterinary clinical pathology. - 1975. - 44(2015), 3 vom: 01. Sept., Seite 405-9 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2015
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| Accès à la collection: | Veterinary clinical pathology |
| Sujets: | Comparative Study Journal Article Athlete's heart cardiac biomarkers cardiac disease congestive heart failure sighthound Biomarkers Peptide Fragments Troponin I plus... |
| Résumé: | © 2015 American Society for Veterinary Clinical Pathology. BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker whose plasma concentration is high in some dogs with cardiopulmonary disease. NT-proBNP is a diagnostic tool that can be used to help determine if a patient has congestive heart failure. Greyhounds have functional heart murmurs, relative cardiomegaly, and high serum cTnI concentration OBJECTIVES: The purpose of the study was to evaluate the plasma concentration of NT-proBNP in healthy Greyhounds and compare it to non-Greyhound dogs METHODS: We prospectively evaluated healthy client-owned dogs including retired racing Greyhounds and non-Greyhounds. Plasma was obtained and transferred into tubes containing a protease inhibitor and submitted for a specific NT-proBNP ELISA assay RESULTS: The plasma NT-proBNP concentration in Greyhounds was significantly higher than in non-Greyhound control dogs (946 vs 632 pmol/L; P < .005); 46% of Greyhounds had NT-proBNP > 1000 pmol/L CONCLUSIONS: Plasma NT-proBNP concentration in Greyhounds is high and should be interpreted with caution |
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| Description: | Date Completed 13.12.2016 Date Revised 30.12.2016 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1939-165X |
| DOI: | 10.1111/vcp.12266 |