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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1111/nph.13455
|2 doi
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|a pubmed24n1223.xml
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|a (NLM)25967461
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Ma, Lisong
|e verfasserin
|4 aut
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|a The AVR2-SIX5 gene pair is required to activate I-2-mediated immunity in tomato
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 20.06.2016
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.
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|a Plant-invading microbes betray their presence to a plant by exposure of antigenic molecules such as small, secreted proteins called 'effectors'. In Fusarium oxysporum f. sp. lycopersici (Fol) we identified a pair of effector gene candidates, AVR2-SIX5, whose expression is controlled by a shared promoter. The pathogenicity of AVR2 and SIX5 Fol knockouts was assessed on susceptible and resistant tomato (Solanum lycopersicum) plants carrying I-2. The I-2 NB-LRR protein confers resistance to Fol races carrying AVR2. Like Avr2, Six5 was found to be required for full virulence on susceptible plants. Unexpectedly, each knockout could breach I-2-mediated disease resistance. So whereas Avr2 is sufficient to induce I-2-mediated cell death, Avr2 and Six5 are both required for resistance. Avr2 and Six5 interact in yeast two-hybrid assays as well as in planta. Six5 and Avr2 accumulate in xylem sap of plants infected with the reciprocal knockouts, showing that lack of I-2 activation is not due to a lack of Avr2 accumulation in the SIX5 mutant. The effector repertoire of a pathogen determines its host specificity and its ability to manipulate plant immunity. Our findings challenge an oversimplified interpretation of the gene-for-gene model by showing requirement of two fungal genes for immunity conferred by one resistance gene
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Fusarium oxysporum
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|a I-2
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|a avirulence
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|a disease resistance
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|a effector proteins
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|a gene-for-gene
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|a tomato (Solanum lycopersicum)
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|a Fungal Proteins
|2 NLM
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| 650 |
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|a Plant Proteins
|2 NLM
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|a Houterman, Petra M
|e verfasserin
|4 aut
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|a Gawehns, Fleur
|e verfasserin
|4 aut
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|a Cao, Lingxue
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|4 aut
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|a Sillo, Fabiano
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|a Richter, Hanna
|e verfasserin
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|a Clavijo-Ortiz, Myriam J
|e verfasserin
|4 aut
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|a Schmidt, Sarah M
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|a Boeren, Sjef
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|a Vervoort, Jacques
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|a Cornelissen, Ben J C
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|a Rep, Martijn
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|a Takken, Frank L W
|e verfasserin
|4 aut
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|i Enthalten in
|t The New phytologist
|d 1979
|g 208(2015), 2 vom: 07. Okt., Seite 507-18
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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|g volume:208
|g year:2015
|g number:2
|g day:07
|g month:10
|g pages:507-18
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|u http://dx.doi.org/10.1111/nph.13455
|3 Volltext
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|d 208
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|h 507-18
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