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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.4008
|2 doi
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|a pubmed24n0829.xml
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|a (DE-627)NLM248689959
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|a (NLM)25941036
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Fernandes, L
|e verfasserin
|4 aut
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|a Long-lived states in an intrinsically disordered protein domain
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 08.10.2015
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|a Date Revised 10.12.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 John Wiley & Sons, Ltd.
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|a Long-lived states (LLS) are relaxation-favored spin population distributions of J-coupled magnetic nuclei. LLS were measured, along with classical (1)H and (15)N relaxation rate constants, in amino acids of the N-terminal Unique domain of the c-Src kinase, which is disordered in vitro under physiological conditions. The relaxation rates of LLS can probe motions and interactions in biomolecules. LLS of the aliphatic protons of glycines, with lifetimes approximately four times longer than their spin-lattice relaxation times, are reported for the first time in an intrinsically disordered protein domain. LLS relaxation experiments were integrated with 2D spectroscopy methods, further adapting them for studies on proteins
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 15N spin
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|a 1H spin
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|a NMR spectroscopy
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|a intrinsically disordered proteins
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|a kinases
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|a long‐lived states
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|a relaxation
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|a Intrinsically Disordered Proteins
|2 NLM
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|a Nitrogen Isotopes
|2 NLM
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|a Protons
|2 NLM
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|a CSK Tyrosine-Protein Kinase
|2 NLM
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|a EC 2.7.10.2
|2 NLM
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|a src-Family Kinases
|2 NLM
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|a EC 2.7.10.2
|2 NLM
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|a CSK protein, human
|2 NLM
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|a EC 2.7.10.23
|2 NLM
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|a Glycine
|2 NLM
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| 650 |
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|a TE7660XO1C
|2 NLM
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| 700 |
1 |
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|a Guerniou, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Marín-Montesinos, I
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pons, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kateb, F
|e verfasserin
|4 aut
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| 700 |
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|a Vasos, P R
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 51(2013), 11 vom: 28. Nov., Seite 729-33
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
1 |
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|g volume:51
|g year:2013
|g number:11
|g day:28
|g month:11
|g pages:729-33
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|u http://dx.doi.org/10.1002/mrc.4008
|3 Volltext
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|d 51
|j 2013
|e 11
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|h 729-33
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