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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.4013
|2 doi
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|a pubmed24n0828.xml
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|a (DE-627)NLM24867367X
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|a (NLM)25939341
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Munavirov, Bulat
|e verfasserin
|4 aut
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1 |
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|a Interaction of polyacrylic acid with lipid bilayers
|b effect of polymer mass
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.10.2015
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|a Date Revised 03.12.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 John Wiley & Sons, Ltd.
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|a Polyanion-coated lipid vesicles are proposed to have an appreciable potential for drug delivery because of their ability to control the permeability of lipid bilayers by environmental parameters such as pH and temperature. However, details of the interaction of this class of polymers with lipids and their mechanisms of induced permeability are still being debated. In this work, we applied (1)H NOESY to study details of the interaction of polyacrylic acid (PAA) fractions of molecular weights 5 and 240 kDa with dimyristoylphosphatidylcholine vesicles. We showed that PAA of two different molecular masses modifies lipid bilayers increasing disorder and probability of close contact between polar and hydrophobic groups. PAA molecules adsorb near the interface of lipid bilayers but do not penetrate into the hydrophobic core of the bilayer and, thus, cannot participate in formation of transbilayer channels, proposed in earlier works. Increasing the molecular mass of PAA from 5 kDa to 240 kDa does not change the effect of PAA on the bilayer, although PAA240 forms a more compact structure (either intra-molecular or inter-molecular) and interacts more strongly with interface lipid protons
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 1H NOESY NMR
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|a biomembrane
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|a polymer
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|a Acrylic Resins
|2 NLM
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|a Lipid Bilayers
|2 NLM
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|a Polyelectrolytes
|2 NLM
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|a Polymers
|2 NLM
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|a Protons
|2 NLM
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|a polyanions
|2 NLM
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| 650 |
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|a carbopol 940
|2 NLM
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| 650 |
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|a 4Q93RCW27E
|2 NLM
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| 650 |
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|a Dimyristoylphosphatidylcholine
|2 NLM
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| 650 |
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|a U86ZGC74V5
|2 NLM
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| 700 |
1 |
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|a Gnezdilov, Oleg
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rudakova, Maya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Antzutkin, Oleg N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Filippov, Andrei
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 51(2013), 11 vom: 08. Nov., Seite 750-5
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
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|g volume:51
|g year:2013
|g number:11
|g day:08
|g month:11
|g pages:750-5
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|u http://dx.doi.org/10.1002/mrc.4013
|3 Volltext
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|d 51
|j 2013
|e 11
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|c 11
|h 750-5
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