Differential expression of CD57 in antigen-reactive CD4+ T cells between active and latent tuberculosis infection

Differential expression of CD57 in antigen-reactive CD4+ T cells between active and latent tuberculosis infection

Copyright © 2015 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 159(2015), 1 vom: 12. Juli, Seite 37-46
1. Verfasser: Lee, Ji Yeon (VerfasserIn)
Weitere Verfasser: Jeong, Ina, Joh, Joon-Sung, Jung, Young Won, Sim, Soo Yeon, Choi, Boram, Jee, Hyeon-Gun, Lim, Dong-Gyun
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Biomarker CD4(+) T cell CD57 Tuberculosis Biomarkers CD57 Antigens PDCD1 protein, human Programmed Cell Death 1 Receptor
Beschreibung
Zusammenfassung:Copyright © 2015 Elsevier Inc. All rights reserved.
The development of diagnostic tests that predict the progression of latent tuberculosis infection to active disease is pivotal for the eradication of tuberculosis. As an initial step to achieve this goal, our study's aim was to identify biomarkers that differentiate active from latent tuberculosis infection. We compared active and latent tuberculosis infection groups in terms of the precursor frequency, functional subset differentiation, and senescence/exhaustion surface marker expression of antigen-specific CD4(+) T cells, which were defined as dividing cells upon their encountering with Mycobacterium (M.) tuberculosis antigens. Among several parameters shown to have statistically significant differences between the two groups, the frequency of CD57-expressing cells could differentiate effectively between active disease and latent infection. Our results suggest that the expression of CD57 in M. tuberculosis-reactive CD4(+) T cells could be a promising candidate biomarker with which to identify individuals with latent tuberculosis infection prone to progression to active disease
Beschreibung:Date Completed 24.08.2015
Date Revised 16.11.2017
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2015.04.011