Tuberculosis specific responses following therapy for TB Impact of HIV co-infection

Tuberculosis specific responses following therapy for TB : Impact of HIV co-infection

Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 159(2015), 1 vom: 13. Juli, Seite 1-12
1. Verfasser: Siddiqui, S (VerfasserIn)
Weitere Verfasser: Sarro, Y, Diarra, B, Diallo, H, Guindo, O, Dabitao, D, Tall, M, Hammond, A, Kassambara, H, Goita, D, Dembele, P, Traore, B, Hengel, R, Nason, M, Warfield, J, Washington, J, Polis, M, Diallo, S, Dao, S, Koita, O, Lane, H C, Catalfamo, M, Tounkara, A
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Intramural CD4+ T cells HIV Tuberculosis Anti-HIV Agents Antigens, Bacterial Antitubercular Agents HLA-DR Antigens IL10 protein, human mehr... IL2 protein, human Interleukin-13 Interleukin-2 Tumor Necrosis Factor-alpha Interleukin-10 130068-27-8 Mycobacterium tuberculosis antigens 144058-44-6 Interleukin-12 187348-17-0 Interferon-gamma 82115-62-6 ADP-ribosyl Cyclase 1 EC 3.2.2.6
Beschreibung
Zusammenfassung:Published by Elsevier Inc.
Characterizing perturbations in the immune response to tuberculosis in HIV can develop insights into the pathogenesis of coinfection. HIV+ TB+ and TB monoinfected (TB+) subjects recruited from clinics in Bamako prior to initiation of TB treatment were evaluated at time-points following initiation of therapy. Flow cytometry assessed CD4+/CD8+ T cell subsets and activation markers CD38/HLA-DR. Antigen specific responses to TB proteins were assessed by intracellular cytokine detection and proliferation. HIV+ TB+ subjects had significantly higher markers of immune activation in the CD4+ and CD8+ T cells compared to TB+ subjects. HIV+ TB+ had lower numbers of TB-specific CD4+ T cells at baseline. Plasma IFNγ levels were similar between HIV+ TB+ and TB+ subjects. No differences were observed in in-vitro proliferative capacity to TB antigens between HIV+ TB+ and TB+ subjects. Subjects with HIV+ TB+ coinfection demonstrate in vivo expansion of TB-specific CD4+ T cells. Immunodeficiency associated with CD4+ T cell depletion may be less significant compared to immunosuppression associated with HIV viremia or untreated TB infection
Beschreibung:Date Completed 24.08.2015
Date Revised 16.11.2017
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2015.04.002