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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erv128
|2 doi
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|a pubmed25n0826.xml
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|a (DE-627)NLM24804916X
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|a (NLM)25873665
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a He, Qin
|e verfasserin
|4 aut
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| 245 |
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|a U-box E3 ubiquitin ligase PUB17 acts in the nucleus to promote specific immune pathways triggered by Phytophthora infestans
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 30.03.2016
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.
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|a Ubiquitination regulates many processes in plants, including immunity. The E3 ubiquitin ligase PUB17 is a positive regulator of programmed cell death (PCD) triggered by resistance proteins CF4/9 in tomato. Its role in immunity to the potato late blight pathogen, Phytophthora infestans, was investigated here. Silencing StPUB17 in potato by RNAi and NbPUB17 in Nicotiana benthamiana by virus-induced gene silencing (VIGS) each enhanced P. infestans leaf colonization. PAMP-triggered immunity (PTI) transcriptional responses activated by flg22, and CF4/Avr4-mediated PCD were attenuated by silencing PUB17. However, silencing PUB17 did not compromise PCD triggered by P. infestans PAMP INF1, or co-expression of R3a/AVR3a, demonstrating that not all PTI- and PCD-associated responses require PUB17. PUB17 localizes to the plant nucleus and especially in the nucleolus. Transient over-expression of a dominant-negative StPUB17(V314I,V316I) mutant, which retained nucleolar localization, suppressed CF4-mediated cell death and enhanced P. infestans colonization. Exclusion of the StPUB17(V314I,V316I) mutant from the nucleus abolished its dominant-negative activity, demonstrating that StPUB17 functions in the nucleus. PUB17 is a positive regulator of immunity to late blight that acts in the nucleus to promote specific PTI and PCD pathways
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Disease resistance
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|a effector-triggered immunity
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|a hypersensitive response
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|a oomycete
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|a plant defence
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|a ubiquitination.
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|a Plant Proteins
|2 NLM
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| 650 |
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|a Ubiquitin-Protein Ligases
|2 NLM
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| 650 |
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|a EC 2.3.2.27
|2 NLM
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| 700 |
1 |
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|a McLellan, Hazel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boevink, Petra C
|e verfasserin
|4 aut
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| 700 |
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|a Sadanandom, Ari
|e verfasserin
|4 aut
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|a Xie, Conghua
|e verfasserin
|4 aut
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|a Birch, Paul R J
|e verfasserin
|4 aut
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|a Tian, Zhendong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 66(2015), 11 vom: 14. Juni, Seite 3189-99
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnas
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| 773 |
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|g volume:66
|g year:2015
|g number:11
|g day:14
|g month:06
|g pages:3189-99
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|u http://dx.doi.org/10.1093/jxb/erv128
|3 Volltext
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|d 66
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|h 3189-99
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