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231224s2015 xx |||||o 00| ||eng c |
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|a 10.3928/23258160-20150323-06
|2 doi
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|a pubmed24n0826.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Rao, Rajesh C
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Gene expression profiling and regression rate of irradiated uveal melanomas
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 16.07.2015
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|a Date Revised 13.11.2018
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright 2015, SLACK Incorporated.
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|a BACKGROUND AND OBJECTIVE: Uveal melanoma is the most common primary intraocular cancer; however, the molecular features that predict response to therapy are poorly understood. Our objective was to determine whether gene expression profiling (GEP) is associated with rate of tumor regression after I-125 plaque brachytherapy for uveal melanoma
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|a PATIENTS AND METHODS: Retrospective review of 138 patients with posterior uveal melanoma treated with I-125 plaque brachytherapy in which GEP class and 3-month post-radiation ultrasonographic tumor thickness data were available. Statistical analysis was performed using t test and Fisher's exact test
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|a RESULTS: GEP class assignment was class 1 in 83 (60.1%) and class 2 in 55 (39.9%) patients. Mean patient age was 60.9 years for class 1 and 68.1 years for class 2 tumors (P = .002). Mean initial tumor diameter was 13.0 mm for class 1 and 14.1 mm for class 2 tumors (P = .02). Mean initial tumor thickness was 5.2 mm for class 1 and 6.1 mm for class 2 tumors (P = .047). Three months after I-125 plaque radiotherapy, mean reduction in tumor thickness was 26.5% for class 1 and 16.7% for class 2 tumors (P = .03)
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|a CONCLUSION: Class 1 uveal melanoma tumors exhibit more rapid early tumor regression than class 2 tumors after I-125 plaque radiotherapy
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|a Journal Article
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|a DNA, Neoplasm
|2 NLM
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| 650 |
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|a Iodine Radioisotopes
|2 NLM
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| 650 |
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|a Neoplasm Proteins
|2 NLM
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| 700 |
1 |
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|a Khan, Mehnaz
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Badiyan, Shahed N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Harbour, J William
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Ophthalmic surgery, lasers & imaging retina
|d 2013
|g 46(2015), 3 vom: 09. März, Seite 333-7
|w (DE-627)NLM224956647
|x 2325-8179
|7 nnns
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| 773 |
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|g volume:46
|g year:2015
|g number:3
|g day:09
|g month:03
|g pages:333-7
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