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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.03.019
|2 doi
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|a pubmed24n0825.xml
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|a eng
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| 100 |
1 |
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|a Charles, Julia F
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The intestinal microbiome and skeletal fitness
|b Connecting bugs and bones
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| 264 |
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a Date Completed 23.11.2015
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|a Date Revised 02.05.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Recent advances have dramatically increased our understanding of how organ systems interact. This has been especially true for immunology and bone biology, where the term "osteoimmunology" was coined to capture this relationship. The importance of the microbiome to the immune system has also emerged as a driver of health and disease. It makes sense therefore to ask the question: how does the intestinal microbiome influence bone biology and does dysbiosis promote bone disease? Surprisingly, few studies have analyzed this connection. A broader interpretation of this question reveals many mechanisms whereby the microbiome may affect bone cells. These include effects of the microbiome on immune cells, including myeloid progenitors and Th17 cells, as well as steroid hormones, fatty acids, serotonin and vitamin D. As mechanistic interactions of the microbiome and skeletal system are revealed within and without the immune system, novel strategies to optimize skeletal fitness may emerge
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a Microbiome
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| 650 |
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|a Osteoblast
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| 650 |
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|a Osteoclast
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| 650 |
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|a Osteoimmunology
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| 650 |
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|a Adrenal Cortex Hormones
|2 NLM
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a Gonadal Steroid Hormones
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|a Ermann, Joerg
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|a Aliprantis, Antonios O
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|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 159(2015), 2 vom: 20. Aug., Seite 163-9
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