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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-015-1449-1
|2 doi
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|a pubmed24n0825.xml
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|a (DE-627)NLM247607681
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|a (NLM)25827684
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Webster, Kirstin H
|e verfasserin
|4 aut
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| 245 |
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|a Assessment of toxicity and coagulopathy of brodifacoum in Japanese quail and testing in wild owls
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 29.02.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Based on detection of hepatic residues, scavenging and predatory non-target raptors are widely exposed to second generation anticoagulant rodenticides (SGARs). A small proportion, generally <10%, of tested birds are diagnosed as acutely poisoned. Little is known, however, of sub-lethal effects of SGARs, such as interaction of clotting capacity with traumatic injury. Assessment of coagulation function of birds submitted live to wildlife rehabilitators or veterinarians may provide a means of establishing the proportion of animals suffering sub-lethal coagulopathies, as well as identifying individuals requiring treatment. As a first step in exploring the potential of this approach, we dosed Japanese quail (Coturnix japonica) with the SGAR, brodifacoum, at 0, 0.8, 1.4, 1.9, and 2.5 mg/kg and sampled birds at 1, 3, 5 and 7 days post-dosing. Prothrombin time (PT), which measures the extrinsic coagulation pathway, was significantly prolonged in 98% of brodifacoum-exposed quail in a dose- and time-dependent manner. 50-fold prolongation of PT occurred at higher brodifacoum dosages and correlated to hemorrhage found at necropsy. Activated clotting time (ACT), a measure of the intrinsic pathway also increased with dose and time. Hemoglobin (Hb) and hematocrit (Hct) decreased dose- and time-dependently at doses ≥1.4 mg/kg with no significant change at 0.8 mg/kg. Reference intervals for PT (10.0-16.2 s), ACT (30-180 s), Hb (9.6-18.4 g/dl), and Hct (34-55%) were established in Japanese quail. Species-specific reference intervals are required as barn owl PT (17-29 s) and quail PT were different. The proportion of brodifacoum-exposed quail with hemorrhage was not correlated with liver residues, but was correlated with PT, suggesting that this assay is a useful indicator of avian anticoagulant rodenticide exposure. PTs measured in free-living barn owls sampled between April 2009 and August 2010 in the lower Fraser Valley of BC do not suggest significant exposure to SGARs
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 4-Hydroxycoumarins
|2 NLM
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| 650 |
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|a Anticoagulants
|2 NLM
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| 650 |
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7 |
|a Rodenticides
|2 NLM
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| 650 |
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|a bromfenacoum
|2 NLM
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| 650 |
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7 |
|a A25P3CP5S7
|2 NLM
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| 700 |
1 |
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|a Harr, Kendal E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bennett, Darin C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Williams, Tony D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Kimberly M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maisonneuve, France
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Elliott, John E
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 24(2015), 5 vom: 15. Juli, Seite 1087-101
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
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|g volume:24
|g year:2015
|g number:5
|g day:15
|g month:07
|g pages:1087-101
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| 856 |
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|u http://dx.doi.org/10.1007/s10646-015-1449-1
|3 Volltext
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|d 24
|j 2015
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|h 1087-101
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