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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b00082
|2 doi
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|a pubmed24n0825.xml
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|a (DE-627)NLM247501190
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|a (NLM)25816726
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Seleci, Muharrem
|e verfasserin
|4 aut
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| 245 |
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|a Nanostructured Amphiphilic Star-Hyperbranched Block Copolymers for Drug Delivery
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.01.2016
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|a Date Revised 25.11.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A robust drug delivery system based on nanosized amphiphilic star-hyperbranched block copolymer, namely, poly(methyl methacrylate-block-poly(hydroxylethyl methacrylate) (PMMA-b-PHEMA) is described. PMMA-b-PHEMA was prepared by sequential visible light induced self-condensing vinyl polymerization (SCVP) and conventional vinyl polymerization. All of the synthesis and characterization details of the conjugates are reported. To accomplish tumor cell targeting property, initially cell-targeting (arginylglycylaspactic acid; RGD) and penetrating peptides (Cys-TAT) were binding to each other via the well-known EDC/NHS chemistry. Then, the resulting peptide was further incorporated to the surface of the amphiphilic hyperbranched copolymer via a coupling reaction between the thiol (-SH) group of the peptide and the hydroxyl group of copolymer by using N-(p-maleinimidophenyl) isocyanate as a heterolinker. The drug release property and targeting effect of the anticancer drug (doxorobucin; DOX) loaded nanostructures to two different cell lines were evaluated in vitro. U87 and MCF-7 were chosen as integrin αvβ3 receptor positive and negative cells for the comparison of the targeting efficiency, respectively. The data showed that drug-loaded copolymers exhibited enhanced cell inhibition toward U87 cells in compared to MCF-7 cells because targeting increased the cytotoxicity of drug-loaded copolymers against integrin αvβ3 receptor expressing tumor cells
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 1-ethyl-3-(3-(diethylamino)propyl)carbodiimide
|2 NLM
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|a Antibiotics, Antineoplastic
|2 NLM
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|a Carbodiimides
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|a Cell-Penetrating Peptides
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|a Cross-Linking Reagents
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|a Cyanates
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|a Integrin alphaVbeta3
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|a Maleimides
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|a Micelles
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|a Oligopeptides
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|a Surface-Active Agents
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|a 4-maleimidophenyl isocyanate
|2 NLM
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|a 123457-83-0
|2 NLM
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|a Polyhydroxyethyl Methacrylate
|2 NLM
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|a 25249-16-5
|2 NLM
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|a arginyl-glycyl-aspartic acid
|2 NLM
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|a 78VO7F77PN
|2 NLM
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|a Doxorubicin
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|a 80168379AG
|2 NLM
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|a Polymethyl Methacrylate
|2 NLM
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|a 9011-14-7
|2 NLM
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| 700 |
1 |
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|a Seleci, Didem Ag
|e verfasserin
|4 aut
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1 |
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|a Ciftci, Mustafa
|e verfasserin
|4 aut
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1 |
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|a Demirkol, Dilek Odaci
|e verfasserin
|4 aut
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|a Stahl, Frank
|e verfasserin
|4 aut
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|a Timur, Suna
|e verfasserin
|4 aut
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|a Scheper, Thomas
|e verfasserin
|4 aut
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|a Yagci, Yusuf
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 31(2015), 15 vom: 21. Apr., Seite 4542-51
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:31
|g year:2015
|g number:15
|g day:21
|g month:04
|g pages:4542-51
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|u http://dx.doi.org/10.1021/acs.langmuir.5b00082
|3 Volltext
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|d 31
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|h 4542-51
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