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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.03.009
|2 doi
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|a pubmed24n0824.xml
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|a (DE-627)NLM247302171
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|a (NLM)25796192
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|a (PII)S1521-6616(15)00099-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Batoulis, Helena
|e verfasserin
|4 aut
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|a Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.07.2015
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|a Date Revised 04.05.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a In multiple sclerosis (MS) lymphoid follicle-like aggregates have been reported in the meninges of patients. Here we investigated the functional relevance of B cell infiltration into the central nervous system (CNS) in MP4-induced experimental autoimmune encephalomyelitis (EAE), a B cell-dependent mouse model of MS. In chronic EAE, B cell aggregates were characterized by the presence of CXCL13(+) and germinal center CD10(+) B cells. Germline transcripts were expressed in the CNS and particularly related to TH17-associated isotypes. We also observed B cells with restricted VH gene usage that differed from clones found in the spleen. Finally, we detected CNS-restricted spreading of the antigen-specific B cell response towards a myelin and a neuronal autoantigen. These data imply the development of autonomous B cell-mediated autoimmunity in the CNS in EAE - a concept that might also apply to MS itself
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a B cells
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|a EAE
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|a Epitope spreading
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|a MS
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|a TLO
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|a Autoantigens
|2 NLM
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|a Chemokine CXCL13
|2 NLM
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|a Cxcl13 protein, mouse
|2 NLM
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| 650 |
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|a Myelin Basic Protein
|2 NLM
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| 650 |
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|a Myelin Proteolipid Protein
|2 NLM
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| 650 |
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|a RNA, Messenger
|2 NLM
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|a Neprilysin
|2 NLM
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| 650 |
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|a EC 3.4.24.11
|2 NLM
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| 700 |
1 |
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|a Wunsch, Marie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Birkenheier, Johannes
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rottlaender, Andrea
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gorboulev, Valentin
|e verfasserin
|4 aut
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| 700 |
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|a Kuerten, Stefanie
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 158(2015), 1 vom: 28. Mai, Seite 47-58
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:158
|g year:2015
|g number:1
|g day:28
|g month:05
|g pages:47-58
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|u http://dx.doi.org/10.1016/j.clim.2015.03.009
|3 Volltext
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