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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.03.005
|2 doi
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|a pubmed24n0824.xml
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|a (DE-627)NLM247254738
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|a (NLM)25791245
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|a (PII)S1521-6616(15)00095-9
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Yang, Yang
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The effect of mycophenolic acid on epigenetic modifications in lupus CD4+T cells
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1 |
|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 07.07.2015
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|a Date Revised 09.11.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease involving multiple organs and characterized by overproduction of autoantibodies and T and B cell abnormalities. The treatment for SLE has been restricted to immunosuppressants and corticosteroids. Mycophenolate mofetil (MMF), as a relatively new immunosuppressant, is now widely used in the treatment of SLE patients, particularly those with nephritis. However, it is unclear whether mycophenolic acid (MPA) could modulate the reported disorders of epigenetic status in CD4(+)T cells from SLE patients. In this study, we demonstrated that MPA can upregulate the histone H3/H4 global acetylation status by regulating HATs and HDACs in lupus CD4(+)T cells. Furthermore, we found that MPA also affected the histone H4 acetylation and histone H3K4 tri-methylation levels in CD40L promoter region that inhibited the expression of CD40L. These findings indicate the potential epigenetic mechanism of therapeutic effects of MPA in SLE
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4 |
|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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4 |
|a CD4(+)T cells
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| 650 |
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4 |
|a CD40L
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| 650 |
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4 |
|a Epigenetics
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|a Mycophenolic acid
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| 650 |
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4 |
|a Systemic lupus erythematosus
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| 650 |
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|a CD11a Antigen
|2 NLM
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| 650 |
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|a CD27 Ligand
|2 NLM
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| 650 |
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|a Enzyme Inhibitors
|2 NLM
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|a Histones
|2 NLM
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| 650 |
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|a RNA, Messenger
|2 NLM
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| 650 |
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|a CD40 Ligand
|2 NLM
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| 650 |
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7 |
|a 147205-72-9
|2 NLM
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| 650 |
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7 |
|a Histone Deacetylases
|2 NLM
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| 650 |
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7 |
|a EC 3.5.1.98
|2 NLM
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| 650 |
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7 |
|a Mycophenolic Acid
|2 NLM
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| 650 |
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7 |
|a HU9DX48N0T
|2 NLM
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| 700 |
1 |
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|a Tang, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liang, Gongping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Haijing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Duo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Yubing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tan, Yixin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dai, Yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yung, Susan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chan, Tak Mao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Qianjin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 158(2015), 1 vom: 01. Mai, Seite 67-76
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:158
|g year:2015
|g number:1
|g day:01
|g month:05
|g pages:67-76
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.03.005
|3 Volltext
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|d 158
|j 2015
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|h 67-76
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