Self-assembled autophagy-inducing polymeric nanoparticles for breast cancer interference in-vivo

Self-assembled autophagy-inducing polymeric nanoparticles for breast cancer interference in-vivo

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 27(2015), 16 vom: 24. Apr., Seite 2627-34
1. Verfasser: Wang, Yi (VerfasserIn)
Weitere Verfasser: Lin, Yao-Xin, Qiao, Zeng-Ying, An, Hong-Wei, Qiao, Sheng-Lin, Wang, Lei, Rajapaksha, R P Yeshan J, Wang, Hao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't breast cancer nanoparticles polymer self-assembly therapeutic peptide Acrylates Antineoplastic Agents Apoptosis Regulatory Proteins mehr... BECN1 protein, human Beclin-1 Membrane Proteins Micelles Polymers poly(beta-amino ester) Polyethylene Glycols 3WJQ0SDW1A 1,6-hexanediol diacrylate FY751V5MMY
Beschreibung
Zusammenfassung:© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A peptide-conjugated poly(β-amino ester) that self-assembles into micelle-like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer-beclin-1 (P-Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small-molecule drugs: poor delivery to tumors owing to enzymatic degradation, and unstable, non-specific bio-distribution and targeting in the tumor tissues
Beschreibung:Date Completed 08.01.2016
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201405926