Toward multifunctional "clickable" diamond nanoparticles

Nanodiamonds (NDs) are among the most promising new carbon based materials for biomedical applications, and the simultaneous integration of various functions onto NDs is an urgent necessity. A multifunctional nanodiamond based formulation is proposed here. Our strategy relies on orthogonal surface m...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1985. - 31(2015), 13 vom: 07. Apr., Seite 3926-33
1. Verfasser: Khanal, Manakamana (VerfasserIn)
Weitere Verfasser: Turcheniuk, Volodymyr, Barras, Alexandre, Rosay, Elodie, Bande, Omprakash, Siriwardena, Aloysius, Zaitsev, Vladimir, Pan, Guo-Hui, Boukherroub, Rabah, Szunerits, Sabine
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Azides Nanodiamonds triethylene glycol 3P5SU53360 Polyethylene Glycols 3WJQ0SDW1A
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500 |a ErratumIn: Langmuir. 2023 Dec 26;39(51):19064. doi: 10.1021/acs.langmuir.3c03543. - PMID 38095219 
500 |a Citation Status MEDLINE 
520 |a Nanodiamonds (NDs) are among the most promising new carbon based materials for biomedical applications, and the simultaneous integration of various functions onto NDs is an urgent necessity. A multifunctional nanodiamond based formulation is proposed here. Our strategy relies on orthogonal surface modification using different dopamine anchors. NDs simultaneously functionalized with triethylene glycol (EG) and azide (-N3) functions were fabricated through a stoichiometrically controlled integration of the dopamine ligands onto the surface of hydroxylated NDs. The presence of EG functionalities rendered NDs soluble in water and biological media, while the -N3 group allowed postsynthetic modification of the NDs using "click" chemistry. As a proof of principle, alkynyl terminated di(amido amine) ligands were linked to these ND particles 
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650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a triethylene glycol  |2 NLM 
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700 1 |a Turcheniuk, Volodymyr  |e verfasserin  |4 aut 
700 1 |a Barras, Alexandre  |e verfasserin  |4 aut 
700 1 |a Rosay, Elodie  |e verfasserin  |4 aut 
700 1 |a Bande, Omprakash  |e verfasserin  |4 aut 
700 1 |a Siriwardena, Aloysius  |e verfasserin  |4 aut 
700 1 |a Zaitsev, Vladimir  |e verfasserin  |4 aut 
700 1 |a Pan, Guo-Hui  |e verfasserin  |4 aut 
700 1 |a Boukherroub, Rabah  |e verfasserin  |4 aut 
700 1 |a Szunerits, Sabine  |e verfasserin  |4 aut 
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