Effect of lipid headgroup charge and pH on the stability and membrane insertion potential of calcium condensed gene complexes

Noncovalently condensed complexes of genetic material, cell penetrating peptides (CPPs), and calcium chloride present a nonviral route to improve transfection efficiency of nucleic acids (e.g., pDNA and siRNA). However, the exact mechanisms of membrane insertion and delivery of macromolecule complex...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 31(2015), 14 vom: 14. Apr., Seite 4232-45
1. Verfasser:	Alhakamy, Nabil A (VerfasserIn)
Weitere Verfasser:	Elandaloussi, Ibrahim, Ghazvini, Saba, Berkland, Cory J, Dhar, Prajnaparamita
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2015
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Cell-Penetrating Peptides Drug Carriers Membranes, Artificial Phospholipids DNA 9007-49-2 Calcium Chloride M4I0D6VV5M