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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.02.011
|2 doi
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|a pubmed25n0822.xml
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|a (DE-627)NLM246714042
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|a (NLM)25732927
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|a (PII)S1521-6616(15)00060-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Shchetynsky, Klementy
|e verfasserin
|4 aut
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| 245 |
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|a Gene-gene interaction and RNA splicing profiles of MAP2K4 gene in rheumatoid arthritis
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 07.07.2015
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|a Date Revised 25.11.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015. Published by Elsevier Inc.
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|a We performed gene-gene interaction analysis, with HLA-DRB1 shared epitope (SE) alleles for 195 SNPs within immunologically important MAP2K, MAP3K and MAP4K gene families, in 2010 rheumatoid arthritis (RA) patients and 2280 healthy controls. We found a significant statistical interaction for rs10468473 with SE alleles in autoantibody-positive RA. Individuals heterozygous for rs10468473 demonstrated higher expression of total MAP2K4 mRNA in blood, compared to A-allele homozygous. We discovered a novel, putatively translated, "cassette exon" RNA splice form of MAP2K4, differentially expressed in peripheral blood mononuclear cells from 88 RA cases and controls. Within the group of RA patients, we observed a correlation of MAP2K4 isoform expression with carried SE alleles, autoantibody, and rheumatoid factor profiles. TNF-dependent modulation of isoform expression pattern was detected in the Jurkat cell line. Our data suggest a genetic interaction between MAP2K4 and HLA-DRB1, and the importance of rs10468473 and MAP2K4 splice variants in the development of autoantibody-positive RA
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Alternative splicing
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|a Gene–gene interaction
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|a MAP2K4
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|a RNA expression
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|a Rheumatoid arthritis
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|a Epitopes
|2 NLM
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|a HLA-DRB1 Chains
|2 NLM
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|a RNA, Messenger
|2 NLM
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|a Tumor Necrosis Factors
|2 NLM
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|a MAP Kinase Kinase 4
|2 NLM
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| 650 |
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|a EC 2.7.12.2
|2 NLM
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| 650 |
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|a MAP2K4 protein, human
|2 NLM
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| 650 |
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|a EC 2.7.12.2
|2 NLM
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| 700 |
1 |
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|a Protsyuk, Darya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ronninger, Marcus
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Diaz-Gallo, Lina-Marcela
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Klareskog, Lars
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Padyukov, Leonid
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 158(2015), 1 vom: 03. Mai, Seite 19-28
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:158
|g year:2015
|g number:1
|g day:03
|g month:05
|g pages:19-28
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|u http://dx.doi.org/10.1016/j.clim.2015.02.011
|3 Volltext
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