Cell Permeable AuZnMoS4 Core-Shell Nanoparticles : Towards a Novel Cellular Copper Detoxifying Drug for Wilson's Disease
A layer-by-layer self-assembly method leads to the formation of AuZnMoS4 core-shell nanoparticles (NPs). The PEGylated Au@ZnMoS4 NPs are highly water-dispersible, exhibit no cytotoxicity and can penetrate the cell membrane to selectively remove copper(I) ions from HepG2 cells in the presence of othe...
| Veröffentlicht in: | Chemistry of materials : a publication of the American Chemical Society. - 1998. - 25(2013), 23 vom: 01., Seite 4703-4709 |
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| Format: | Aufsatz |
| Sprache: | English |
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2013
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| Zugriff auf das übergeordnete Werk: | Chemistry of materials : a publication of the American Chemical Society |
| Schlagworte: | Journal Article Biomedical Applications Core/Shell Nanoparticles Drug Delivery Functional Coatings Gold Nanoparticles Layer-by-Layer Self-Assembly |
| Zusammenfassung: | A layer-by-layer self-assembly method leads to the formation of AuZnMoS4 core-shell nanoparticles (NPs). The PEGylated Au@ZnMoS4 NPs are highly water-dispersible, exhibit no cytotoxicity and can penetrate the cell membrane to selectively remove copper(I) ions from HepG2 cells in the presence of other endogenous and biologically essential metal ions including Mg(II), Ca(II), Mn(II) and Fe(II), demonstrating their potential as a novel intracellular copper detoxifying agent |
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| Beschreibung: | Date Revised 20.11.2019 published: Print Citation Status PubMed-not-MEDLINE |
| ISSN: | 0897-4756 |