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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/la504503w
|2 doi
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|a pubmed24n0820.xml
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|a (DE-627)NLM246135840
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|a (NLM)25671295
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Elahi, M Fazley
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Surface modification of silk fibroin fabric using layer-by-layer polyelectrolyte deposition and heparin immobilization for small-diameter vascular prostheses
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1 |
|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 24.11.2015
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|a Date Revised 03.03.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a There is an urgent need to develop a biologically active implantable small-diameter vascular prosthesis with long-term patency. Silk-fibroin-based small-diameter vascular prosthesis is a promising candidate having higher patency rate; however, the surface modification is indeed required to improve its further hemocompatibility. In this study, silk fibroin fabric was modified by a two-stage process. First, the surface of silk fibroin fabric was coated using a layer-by-layer polyelectrolyte deposition technique by stepwise dipping the silk fibroin fabric into a solution of cationic poly(allylamine hydrochloride) (PAH) and anionic poly(acrylic acid) (PAA) solution. The dipping procedure was repeated to obtain the PAH/PAA multilayers deposited on the silk fibroin fabrics. Second, the polyelectrolyte-deposited silk fibroin fabrics were treated in EDC/NHS-activated low-molecular-weight heparin (LMWH) solution at 4 °C for 24 h, resulting in immobilization of LMWH on the silk fibroin fabrics surface. Scanning electron microscopy, atomic force microscopy, and energy-dispersive X-ray data revealed the accomplishment of LMWH immobilization on the polyelectrolyte-deposited silk fibroin fabric surface. The higher the number of PAH/PAA coating layers on the silk fibroin fabric, the more surface hydrophilicity could be obtained, resulting in a higher fetal bovine serum protein and platelets adhesion resistance properties when tested in vitro. In addition, compared with untreated sample, the surface-modified silk fibroin fabrics showed negligible loss of bursting strength and thus reveal the acceptability of polyelectrolytes deposition and heparin immobilization approach for silk-fibroin-based small-diameter vascular prostheses modification
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4 |
|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Electrolytes
|2 NLM
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| 650 |
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7 |
|a Polymers
|2 NLM
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| 650 |
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7 |
|a Silk
|2 NLM
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| 650 |
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7 |
|a Heparin
|2 NLM
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| 650 |
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7 |
|a 9005-49-6
|2 NLM
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| 650 |
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7 |
|a Fibroins
|2 NLM
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| 650 |
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7 |
|a 9007-76-5
|2 NLM
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| 700 |
1 |
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|a Guan, Guoping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Xinzhe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Fujun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a King, Martin W
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 31(2015), 8 vom: 03. März, Seite 2517-26
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
8 |
|g volume:31
|g year:2015
|g number:8
|g day:03
|g month:03
|g pages:2517-26
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/la504503w
|3 Volltext
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|a GBV_ILN_721
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|a AR
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| 952 |
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|d 31
|j 2015
|e 8
|b 03
|c 03
|h 2517-26
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