Gossypol-cross-linked boronic acid-modified hydrogels : a functional matrix for the controlled release of an anticancer drug

Anticancer drug gossypol cross-links phenylboronic acid-modified acrylamide copolymer chains to form a hydrogel matrix. The hydrogel is dissociated in an acidic environment (pH 4.5), and its dissociation is enhanced in the presence of lactic acid (an α-hydroxy carboxylic acid) as compared to formic...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 31(2015), 7 vom: 24. Feb., Seite 2237-42
1. Verfasser:	Heleg-Shabtai, Vered (VerfasserIn)
Weitere Verfasser:	Aizen, Ruth, Orbach, Ron, Aleman-Garcia, Miguel Angel, Willner, Itamar
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2015
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Antineoplastic Agents Boronic Acids Delayed-Action Preparations Formates Hydrogels formic acid 0YIW783RG1 Lactic Acid mehr... 33X04XA5AT Gossypol KAV15B369O