Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases

Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases

Copyright © 2015 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 157(2015), 2 vom: 07. Apr., Seite 114-20
1. Verfasser: Ichinose, Kunihiro (VerfasserIn)
Weitere Verfasser: Arima, Kazuhiko, Ushigusa, Takeshi, Nishino, Ayako, Nakashima, Yoshikazu, Suzuki, Takahisa, Horai, Yoshiro, Nakajima, Hideki, Kawashiri, Shin-Ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Motomura, Masakatsu, Kawakami, Atsushi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Cerebrospinal fluid Cytokine profiles Neuropsychiatric systemic lupus erythematosus Weighted-voting algorithm Cytokines IL15 protein, human IL2 protein, human IL5 protein, human mehr... Interleukin-15 Interleukin-17 Interleukin-2 Interleukin-5 Fibroblast Growth Factor 2 103107-01-3 Interferon-gamma 82115-62-6
Beschreibung
Zusammenfassung:Copyright © 2015 Elsevier Inc. All rights reserved.
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in SLE. Although the mechanism of NPSLE remains unclear, cytokines and chemokines are considered to be involved in their pathogenesis. Here we used Bio-Plex Pro assays to examine 27 types of cytokines and chemokines in the cerebrospinal fluid (CSF) of 32 NPSLE patients. We used the CSF of 20 patients with multiple sclerosis (MS) and 22 patients with neuromyelitis optica (NMO) as a disease control group. Fourteen of 27 cytokines/chemokines were significantly higher in the NPSLE patients compared to the MS/NMO patients. We could identify six "minimum predictive markers" by using a weighted-voting algorithm that could distinguish NPSLE from MS and NMO: interleukin (IL)-17, IL-2, interferon (IFN)-γ, IL-5, basic fibroblast growth factor (FGF)-basic and IL-15. The determination of various types of CSF cytokine profiles may contribute to the diagnosis of NPSLE and may help elucidate the mechanisms underlying this disease
Beschreibung:Date Completed 29.06.2015
Date Revised 18.03.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2015.01.010