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NLM245637435 |
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DE-627 |
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20250218023314.0 |
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231224s2014 xx ||||| 00| ||chi c |
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|a pubmed25n0818.xml
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|a (DE-627)NLM245637435
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|a (NLM)25619349
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Chen, Rongxin
|e verfasserin
|4 aut
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| 245 |
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|a Central venous-to-arterial carbon dioxide difference in critically ill pediatric patients with septic shock
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 30.03.2015
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|a Date Revised 02.12.2018
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To assess the value of central venous-to-arterial carbon dioxide difference [ P( cv-a) CO₂] in evaluation of disease severity and prognosis in children with septic shock who already had central venous oxygen saturation (ScvO₂) higher than 70% after early resuscitation
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|a METHOD: In this prospective study, 48 septic shock children seen in Shanghai Children's Hospital, Shanghai Jiao Tong University were enrolled from Jun 2012 to May 2014. 36(75.0%) were male, 12 (25.0%) were female, the average age was (31.9 ± 24.5) months. The critically ill patients with septic shock were treated to achieve ScvO₂greater than 70% depending on early goal-directed therapy (EGDT). All patients were divided into two groups, based on P(cv-a)CO₂, low P(cv-a)CO₂group with P(cv-a)CO₂< 6 mmHg (1 mmHg = 0.133 kPa) and high P(cv-a)CO₂group with P(cv-a)CO₂≥ 6 mmHg. The parameters of hemodynamics including mean blood pressure (MAP), heart rate (HR), central venous pressure (CVP), perfusion-related parameters [ScvO₂, P(cv-a)CO₂, serum lactate (Lac), Lac clearance rate], pediatric critical illness score, PRISMIII score, and 28 days in-hospital mortality were recorded for all patients
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|a RESULT: Of the 48 cases with septic shock whose ScvO₂was higher than 70%, 17 patients (35.4%) had high P(cv-a)CO₂( ≥ 6 mmHg) and 31 (65.6%) had lower P(cv-a)CO₂(<6 mmHg). There were no significant differences between the 2 groups of patients in age, PRISMIII score and PCIS (P > 0.05 ), but Lac and P(cv-a)CO₂values were significantly different ( P < 0.05). Low P(cv-a) CO₂group patients had lower 28 days mortality than high P(cv-a) CO₂group[11/17 vs. 32.3% (10/31), P < 0.05]; 24 h after resuscitation, compared with high P(cv-a) CO₂group, low P(cv-a) CO₂group patients had lower Lac values [(2.0 ± 1.3) vs.( 2.7 ± 1.2) mmol/L, P < 0.05]. Low P(cv-a) CO₂group patients had shorter duration of vasoactive drugs use [(16 ± 14) vs. (44 ± 21)h, P < 0.05], 24 h Lac clearance rate was significantly higher for low P(cv-a) CO₂group than for high P(cv-a) CO₂group[ (31 ± 10) % vs. (26 ± 6)%, P < 0.05]
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|a CONCLUSION: When ScvO₂> 70% was achieved after early resuscitation in septic shock children, P(cv-a) CO₂is a sensitive biomarker to assess tissue perfusion, and high P(cv-a) CO₂group patients had poor outcome
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|a Journal Article
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7 |
|a Carbon Dioxide
|2 NLM
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| 650 |
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7 |
|a 142M471B3J
|2 NLM
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| 650 |
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|a Lactic Acid
|2 NLM
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| 650 |
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7 |
|a 33X04XA5AT
|2 NLM
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| 700 |
1 |
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|a Zhang, Yucai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cui, Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miao, Huijie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Liang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rong, Qunfang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 52(2014), 12 vom: 14. Dez., Seite 918-22
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
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|g volume:52
|g year:2014
|g number:12
|g day:14
|g month:12
|g pages:918-22
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|a GBV_ILN_11
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|a AR
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|d 52
|j 2014
|e 12
|b 14
|c 12
|h 918-22
|