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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.01.005
|2 doi
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|a pubmed25n0818.xml
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|a (DE-627)NLM24542928X
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|a (NLM)25597827
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|a (PII)S1521-6616(15)00007-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Sachdeva, Naresh
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Preproinsulin specific CD8+ T cells in subjects with latent autoimmune diabetes show lower frequency and different pathophysiological characteristics than those with type 1 diabetes
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 18.05.2015
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|a Date Revised 11.03.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Latent autoimmune diabetes in adults (LADA) resembles type 1 diabetes (T1D) in disease presentation except that its onset is slow. We compared pathophysiological characteristics of CD8+ T cells recognizing preproinsulin (PPI) derived epitopes in both disease groups using MHC-I dextramers (DMRs) in peripheral blood and after in-vitro stimulation with PPI. Subjects with T1D harbored higher frequency of DMR+ CD8+ T cells with relatively higher frequency of effector T cell subsets. Following stimulation with PPI, an increase in DMR+ CD8+ T cells, particularly the central-memory subset was observed in T1D group, whereas no significant change in DMR+ CD8+ T cell subsets was observed in LADA group. Intracellular expression of Granzyme-B and Perforin in DMR+ CD8+ T cells was comparable in both the groups. In conclusion, lower frequency and inferior proliferative potential on account of a relatively restrained central-memory subset of PPI specific CD8+ T cells are associated with slow rate of disease progression in LADA
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CD8+ T cells
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| 650 |
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4 |
|a Dextramers
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|a Latent autoimmune diabetes in adults
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|a Preproinsulin
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|a Type 1 diabetes
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| 650 |
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|a Insulin
|2 NLM
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| 650 |
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|a Protein Precursors
|2 NLM
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| 650 |
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|a preproinsulin
|2 NLM
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| 650 |
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|a 61116-24-3
|2 NLM
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| 700 |
1 |
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|a Paul, Mahinder
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Badal, Darshan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kumar, Rajendra
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jacob, Neenu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dayal, Devi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bhansali, Anil
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Arora, Sunil Kumar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bhadada, Sanjay Kumar
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 157(2015), 1 vom: 19. März, Seite 78-90
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:157
|g year:2015
|g number:1
|g day:19
|g month:03
|g pages:78-90
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.01.005
|3 Volltext
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