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20231224140831.0 |
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231224s2015 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2015.01.001
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0818.xml
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|a (DE-627)NLM245415742
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|a (NLM)25596452
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|a (PII)S1521-6616(15)00003-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Blauth, Kevin
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis
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| 264 |
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1 |
|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 29.06.2015
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| 500 |
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Fractalkine (CX3CL1) levels are increased in the cerebrospinal fluid (CSF) of patients with clinically isolated syndrome (CIS), as well as in the CSF and serum samples from patients with relapsing-remitting multiple sclerosis (RRMS). A higher percentage of circulating CD4(+) T-cells expressed its surface receptor (CX3CR1) and intracellular adhesion molecule (ICAM-1) in RRMS patients in comparison to healthy controls (HCs). The CX3CR1(+)ICAM-1(+)CD4(+) T-cells are enriched in the CSF of the RRMS patients. In vitro migration studies revealed that CD4(+) T-cells, which migrated toward a CX3CL1 gradient, expressed higher levels of ICAM-1 than non-migrating cells. CX3CL1 significantly increased IFN-γ and TNF-α gene expression and IFN-γ secretion by CD4(+) T-cells derived from the RRMS patients. CX3CL1 upregulated ICAM-1 expression on the surface of RRMS patient-derived but not HC-derived CD4(+) T-cells. Thus, CX3CL1 induces recruitment of CX3CR1(+)ICAM-1(+)CD4(+) T-cells into the central nervous system (CNS) during the early inflammatory response in MS
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a CX3CL1;
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| 650 |
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4 |
|a CX3CR1;
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| 650 |
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4 |
|a ICAM-1;
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| 650 |
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4 |
|a IFN-γ;
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| 650 |
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4 |
|a Multiple sclerosis
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| 650 |
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4 |
|a TNF-α;
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| 650 |
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7 |
|a CX3C Chemokine Receptor 1
|2 NLM
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| 650 |
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7 |
|a CX3CL1 protein, human
|2 NLM
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| 650 |
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7 |
|a CX3CR1 protein, human
|2 NLM
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| 650 |
|
7 |
|a Chemokine CX3CL1
|2 NLM
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| 650 |
|
7 |
|a ICAM1 protein, human
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a Receptors, Chemokine
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
|
7 |
|a Intercellular Adhesion Molecule-1
|2 NLM
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| 650 |
|
7 |
|a 126547-89-5
|2 NLM
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| 650 |
|
7 |
|a Interferon-gamma
|2 NLM
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| 650 |
|
7 |
|a 82115-62-6
|2 NLM
|
| 700 |
1 |
|
|a Zhang, Xin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chopra, Manisha
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rogan, Sarah
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Markovic-Plese, Silva
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 157(2015), 2 vom: 01. Apr., Seite 121-32
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:157
|g year:2015
|g number:2
|g day:01
|g month:04
|g pages:121-32
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2015.01.001
|3 Volltext
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 157
|j 2015
|e 2
|b 01
|c 04
|h 121-32
|