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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.jplph.2014.12.004
|2 doi
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|a pubmed24n1223.xml
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|a (DE-627)NLM244923922
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|a (NLM)25544587
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|a (PII)S0176-1617(14)00348-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Zulet, Amaia
|e verfasserin
|4 aut
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|a Fermentation and alternative oxidase contribute to the action of amino acid biosynthesis-inhibiting herbicides
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 23.02.2016
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier GmbH. All rights reserved.
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|a Acetolactate synthase inhibitors (ALS-inhibitors) and glyphosate (GLP) are two classes of herbicide that act by the specific inhibition of an enzyme in the biosynthetic pathway of branched-chain or aromatic amino acids, respectively. The physiological effects that are detected after application of these two classes of herbicides are not fully understood in relation to the primary biochemical target inhibition, although they have been well documented. Interestingly, the two herbicides' toxicity includes some common physiological effects suggesting that they kill the treated plants by a similar pattern despite targeting different enzymes. The induction of aerobic ethanol fermentation and alternative oxidase (AOX) are two examples of these common effects. The objective of this work was to gain further insight into the role of fermentation and AOX induction in the toxic consequences of ALS-inhibitors and GLP. For this, Arabidopsis T-DNA knockout mutants of alcohol dehydrogenase (ADH) 1 and AOX1a were used. The results found in wild-type indicate that both GLP and ALS-inhibitors reduce ATP production by inducing fermentation and alternative respiration. The main physiological effects in the process of herbicide activity upon treated plants were accumulation of carbohydrates and total free amino acids. The effects of the herbicides on these parameters were less pronounced in mutants compared to wild-type plants. The role of fermentation and AOX regarding pyruvate availability is also discussed
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|a Journal Article
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|a Acetolactate synthase inhibitors
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|a Arabidopsis thaliana
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|a Ethanol fermentation
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|a Glyphosate
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|a Physiological effects
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|a Amino Acids
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|a Arabidopsis Proteins
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|a Herbicides
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|a Mitochondrial Proteins
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|a Plant Proteins
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|a Pyruvic Acid
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|a 8558G7RUTR
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|a Oxidoreductases
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|a EC 1.-
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|a alternative oxidase
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|a EC 1.-
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|a Acetolactate Synthase
|2 NLM
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|a EC 2.2.1.6
|2 NLM
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|a Oxygen
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|a S88TT14065
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|a Glycine
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|a TE7660XO1C
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|a Gil-Monreal, Miriam
|e verfasserin
|4 aut
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|a Zabalza, Ana
|e verfasserin
|4 aut
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|a van Dongen, Joost T
|e verfasserin
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|a Royuela, Mercedes
|e verfasserin
|4 aut
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|i Enthalten in
|t Journal of plant physiology
|d 1979
|g 175(2015) vom: 01. März, Seite 102-12
|w (DE-627)NLM098174622
|x 1618-1328
|7 nnns
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|g volume:175
|g year:2015
|g day:01
|g month:03
|g pages:102-12
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|u http://dx.doi.org/10.1016/j.jplph.2014.12.004
|3 Volltext
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|d 175
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|h 102-12
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