Antibody dissociation rates are predictive of neutralizing antibody (NAb) course a comparison of interferon beta-1b-treated Multiple Sclerosis (MS) patients with transient versus sustained NAbs

Antibody dissociation rates are predictive of neutralizing antibody (NAb) course : a comparison of interferon beta-1b-treated Multiple Sclerosis (MS) patients with transient versus sustained NAbs

Copyright © 2014 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 157(2015), 1 vom: 28. März, Seite 91-101
1. Verfasser: Gibbs, Ebrima (VerfasserIn)
Weitere Verfasser: Karim, Mohammad Ehsanul (BerichterstatterIn), Oger, Joel (BerichterstatterIn), Steering Committee of the BENEFIT study (BerichterstatterIn), Edan, Gilles (BerichterstatterIn), Freedman, Mark S (BerichterstatterIn), Hartung, Hans Peter (BerichterstatterIn), Miller, David (BerichterstatterIn), Montalbán, Xavier (BerichterstatterIn), Pleimes, Dirk (BerichterstatterIn), Pohl, Christoph, Polman, Chris, Sandbrink, Rupert
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Antibody dissociation rate; Biacore™ Immunogenicity; Interferon beta; Multiple sclerosis; Transient and sustainedneutralizing antibody; mehr... Antibodies, Neutralizing Interferon beta-1b 145155-23-3 Interferon-beta 77238-31-4
Beschreibung
Zusammenfassung:Copyright © 2014 Elsevier Inc. All rights reserved.
A proportion of multiple sclerosis (MS) patients treated with interferon-β (IFNβ) develop neutralizing antibodies (NAbs), which can reduce therapeutic efficacy. In the Betaseron/Betaferon in Newly Emerging MS for Initial Treatment (BENEFIT) study, 88/277 patients developed NAbs, 48 having transient positivity and 29 having sustained positivity. This study aimed to investigate the antibody binding characteristics of serial sera in a subset of these two patient groups. Using Biacore™, a surface plasmon resonance-based technology that monitors biomolecular interactions in real time, we immobilized pure IFNβ-1b and analyzed antibody binding responses and dissociation rates of these sera. NAb titers correlated directly with binding responses and inversely with dissociation rates, and sera from sustained NAb patients demonstrated significantly higher binding responses and slower dissociation rates than sera from transient NAb patients. Thus, transient and sustained NAbs are quantitatively and qualitatively different, and interestingly, binding responses and dissociation rates at month 12 could predict the NAb course
Beschreibung:Date Completed 18.05.2015
Date Revised 19.11.2015
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2014.12.005