Fabrication of a nanofibrous mat with a human skin pattern
A number of studies on skin tissue regeneration and wound healing have been conducted. Electrospun nanofibers have numerous advantages for use in wound healing dressings. Here, we present an electrospinning method for alteration of the surface morphological properties of electrospun mats because mos...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 31(2015), 1 vom: 02., Seite 424-31 |
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| Weitere Verfasser: | , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2015
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Biocompatible Materials |
| Zusammenfassung: | A number of studies on skin tissue regeneration and wound healing have been conducted. Electrospun nanofibers have numerous advantages for use in wound healing dressings. Here, we present an electrospinning method for alteration of the surface morphological properties of electrospun mats because most previous studies focused on the materials used or the introduction of bioactive healing agents. In this study, a micromachined human skin pattern mold was used as a collector in an electrospinning setup to replicate the pattern onto the surface of the electrospun mat. We demonstrated the successful fabrication of a nanofibrous mat with a human skin pattern. To verify its suitability for wound healing, a 14-day in vitro cell culture was carried out. The results indicated that the fabricated mat not only induces equivalent cell viability to the conventional electrospun mat, but also exhibits guidance of cells along the skin pattern without significant deterioration of pattern geometry |
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| Beschreibung: | Date Completed 16.02.2016 Date Revised 13.01.2015 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la503064r |