Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease

Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease

Copyright © 2014. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 156(2015), 1 vom: 30. Jan., Seite 9-18
1. Verfasser: Furukawa, Sachiko (VerfasserIn)
Weitere Verfasser: Moriyama, Masafumi, Tanaka, Akihiko, Maehara, Takashi, Tsuboi, Hiroto, Iizuka, Mana, Hayashida, Jun-Nosuke, Ohta, Miho, Saeki, Takako, Notohara, Kenji, Sumida, Takayuki, Nakamura, Seiji
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't CCL18 Fibrosis; IL-10; IgG4-related dacryoadenitis and sialoadenitis; M2 macrophage; CCL18 protein, human Chemokines, CC Immunoglobulin G mehr... Interleukin-10 130068-27-8
Beschreibung
Zusammenfassung:Copyright © 2014. Published by Elsevier Inc.
IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by bilateral swelling of glandular tissues with extensive fibrosis, and is immunologically considered a Th2-predominant disease. Recent studies reported that alternatively activated (M2) macrophages enhanced Th2 immune responses and fibrosis by production of pro-fibrotic factors (IL-10, IL-13 and CCL18). Therefore, we examined the association between M2 macrophages and fibrosis in submandibular glands from 7 patients with IgG4-DS, 10 patients with chronic sialoadenitis, 10 patients with Sjögren's syndrome, and 10 healthy subjects. The number of M2 macrophages in SMGs from patients with IgG4-DS was also significantly higher than in the other groups. Double immunofluorescence staining showed that IL-10 and CCL18 expression co-localized with M2 macrophage-marker (CD163). Furthermore, the SMG fibrosis score was positively correlated with the frequency of M2 macrophages in only IgG4-DS. These results indicate that IL-10 and CCL18 secreted by preferential M2 macrophages possibly play a key role in the development of severe fibrosis in IgG4-DS
Beschreibung:Date Completed 26.02.2015
Date Revised 17.03.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2014.10.008