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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1021/la504097f
|2 doi
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|a eng
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|a Zhou, Yi
|e verfasserin
|4 aut
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|a Ion channel probes for scanning ion conductance microscopy
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a Date Completed 13.08.2015
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The sensitivity and selectivity of ion channels provide an appealing opportunity for sensor development. Here, we describe ion channel probes (ICPs), which consist of multiple ion channels reconstituted into lipid bilayers suspended across the opening of perflourinated glass micropipets. When incorporated with a scanning ion conductance microscope (SICM), ICPs displayed a distance-dependent current response that depended on the number of ion channels in the membrane. With distance-dependent current as feedback, probes were translated laterally, to demonstrate the possibility of imaging with ICPs. The ICP platform yields several potential advantages for SICM that will enable exciting opportunities for incorporation of chemical information into imaging and for high-resolution imaging
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Ion Channels
|2 NLM
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|a Lipid Bilayers
|2 NLM
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|a Bright, Leonard K
|e verfasserin
|4 aut
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|a Shi, Wenqing
|e verfasserin
|4 aut
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|a Aspinwall, Craig A
|e verfasserin
|4 aut
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|a Baker, Lane A
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 30(2014), 50 vom: 23. Dez., Seite 15351-5
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|g year:2014
|g number:50
|g day:23
|g month:12
|g pages:15351-5
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