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231224s2014 xx |||||o 00| ||eng c |
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|a 10.3928/23258160-20141118-08
|2 doi
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|a pubmed25n0812.xml
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|a (NLM)25423633
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|a DE-627
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|e rakwb
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|a eng
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|a Byon, Ik Soo
|e verfasserin
|4 aut
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|a Reduced-fluence photodynamic therapy in polypoidal choroidal vasculopathy nonresponsive to ranibizumab
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 11.05.2015
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|a Date Revised 02.12.2018
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright 2014, SLACK Incorporated.
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|a BACKGROUND AND OBJECTIVE: To evaluate the effect of reduced-fluence photodynamic therapy (PDT) on polypoidal choroidal vasculopathy (PCV) unresponsive to intravitreal ranibizumab
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|a PATIENTS AND METHODS: Patients with PCV unresponsive to ranibizumab administered 3 months consecutively who then received reduced-fluence PDT were retrospectively surveyed. Nonresponders were defined as patients having no reduction in intraretinal and/or subretinal fluid after 3 consecutive treatments
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|a RESULTS: In total, 22 of 104 eyes (21.2%) were non-responders, and 16 of 22 nonresponders received reduced-fluence PDT. Nine eyes achieved complete fluid resolution, and six had reduced but persistent fluid. In one eye, fluid persisted at 6 months despite an additional anti-vascular endothelial growth factor (anti-VEGF) injection after reduced-fluence PDT. Mean macular thickness decreased significantly at 3 and 6 months after PDT, but the mean visual acuity was worse than baseline
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|a CONCLUSION: Reduced-fluence PDT in nonresponders gradually decreased intraretinal and/or subretinal fluid over several months but did not maintain visual acuity
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|a Journal Article
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|a Angiogenesis Inhibitors
|2 NLM
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|a Antibodies, Monoclonal, Humanized
|2 NLM
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|a Coloring Agents
|2 NLM
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|a Photosensitizing Agents
|2 NLM
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|a Porphyrins
|2 NLM
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|a VEGFA protein, human
|2 NLM
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|a Vascular Endothelial Growth Factor A
|2 NLM
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|a Verteporfin
|2 NLM
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|a 0X9PA28K43
|2 NLM
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|a Indocyanine Green
|2 NLM
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|a IX6J1063HV
|2 NLM
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|a Ranibizumab
|2 NLM
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|a ZL1R02VT79
|2 NLM
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|a Kwon, Han Jo
|e verfasserin
|4 aut
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|a Kim, Sung Il
|e verfasserin
|4 aut
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1 |
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|a Shin, Min Kyu
|e verfasserin
|4 aut
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|a Park, Sung Who
|e verfasserin
|4 aut
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|a Lee, Ji Eun
|e verfasserin
|4 aut
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|i Enthalten in
|t Ophthalmic surgery, lasers & imaging retina
|d 2013
|g 45(2014), 6 vom: 21. Nov., Seite 534-41
|w (DE-627)NLM224956647
|x 2325-8179
|7 nnas
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|g volume:45
|g year:2014
|g number:6
|g day:21
|g month:11
|g pages:534-41
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|u http://dx.doi.org/10.3928/23258160-20141118-08
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