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231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la502473w
|2 doi
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|a pubmed24n0810.xml
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|a (DE-627)NLM243013442
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|a (NLM)25340527
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Duncanson, Wynter J
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Microfluidic fabrication of perfluorohexane-shelled double emulsions for controlled loading and acoustic-triggered release of hydrophilic agents
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.10.2015
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|a Date Revised 26.11.2014
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The ability of low boiling point liquid perfluorocarbons (PFCs) to undergo a phase change from a liquid to a gas upon ultrasound irradiation makes PFC-based emulsions promising vehicles for triggered delivery of payloads. However, loading hydrophilic agents into PFC-based emulsions is difficult due to their insolubility in PFC. Here, we address this challenge by taking advantage of microfluidic technologies to fabricate double emulsions consisting of large aqueous cores and a perfluorohexane (PFH) shell, thus yielding high loading capacities for hydrophilic agents. Using this technology, we efficiently encapsulate a model hydrophilic agent within the emulsions and study its response to ultrasound irradiation. Using a combination of optical and acoustic imaging methods, we observe payload release upon acoustic vaporization of PFH. Our work demonstrates the utility of microfluidic techniques for controllably loading hydrophilic agents into PFH-based emulsions, which have great potential for acoustically triggered release
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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7 |
|a Drug Carriers
|2 NLM
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| 650 |
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7 |
|a Emulsions
|2 NLM
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| 650 |
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7 |
|a Fluorocarbons
|2 NLM
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| 650 |
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7 |
|a perflexane
|2 NLM
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| 650 |
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7 |
|a FX3WJ41CMX
|2 NLM
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| 700 |
1 |
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|a Arriaga, Laura R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ung, W Lloyd
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kopechek, Jonathan A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Porter, Tyrone M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Weitz, David A
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 30(2014), 46 vom: 25. Nov., Seite 13765-70
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:30
|g year:2014
|g number:46
|g day:25
|g month:11
|g pages:13765-70
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| 856 |
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|u http://dx.doi.org/10.1021/la502473w
|3 Volltext
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|a AR
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|d 30
|j 2014
|e 46
|b 25
|c 11
|h 13765-70
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