Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices
The lysosomal acid ceramidase, an enzyme known to limit intracellular ceramide accumulation, has been reported to be defective in neurodegenerative disorders. We show here that rat hippocampal slices, preincubated with the acid ceramidase inhibitor (ACI) d-NMAPPD, exhibit increased N-methyl-D-aspart...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Neural plasticity. - 1998. - 2014(2014) vom: 13., Seite 196812
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| 1. Verfasser: |
Laurier-Laurin, Marie-Elaine
(VerfasserIn) |
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| Weitere Verfasser: |
De Montigny, Audrée,
Attiori Essis, Suzanne,
Cyr, Michel,
Massicotte, Guy |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2014
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| Zugriff auf das übergeordnete Werk: | Neural plasticity
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol
Myristates
NR2B NMDA receptor
Propanolamines
Receptors, N-Methyl-D-Aspartate
tau Proteins
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
mehr...
Acid Ceramidase
EC 3.5.1.23
Asah1 protein, rat |
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