Structure of pravastatin and its complex with sodium dodecyl sulfate micelles studied by NMR spectroscopy

Structure of pravastatin and its complex with sodium dodecyl sulfate micelles studied by NMR spectroscopy

Copyright © 2014 John Wiley & Sons, Ltd.

Bibliographische Detailangaben
Veröffentlicht in:Magnetic resonance in chemistry : MRC. - 1985. - 53(2015), 2 vom: 24. Feb., Seite 110-4
1. Verfasser: Galiullina, L F (VerfasserIn)
Weitere Verfasser: Rakhmatullin, I Z, Klochkova, E A, Aganov, A V, Klochkov, V V
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Magnetic resonance in chemistry : MRC
Schlagworte:Journal Article Research Support, Non-U.S. Gov't NMR spectroscopy biophysical models complexation micelle nuclear overhauser effect pravastatin sodium dodecyl sulfate surfactants mehr... Micelles Sodium Dodecyl Sulfate 368GB5141J Pravastatin KXO2KT9N0G
Beschreibung
Zusammenfassung:Copyright © 2014 John Wiley & Sons, Ltd.
The aim of this work was to study the mechanisms of interaction between pravastatin and cell membranes using model membranes (sodium dodecyl sulfate micelles) by nuclear magnetic resonance spectroscopy methods. On the basis of the nuclear magnetic resonance experiments, it was established that pravastatin can form intermolecular complexes with sodium dodecyl sulfate micelles by the interaction of its hydrophilic groups with the polar surface of the micelle. Conformational features of pravastatin molecule were also studied
Beschreibung:Date Completed 29.09.2015
Date Revised 23.01.2015
published: Print-Electronic
Citation Status MEDLINE
ISSN:1097-458X
DOI:10.1002/mrc.4146