|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM242173853 |
| 003 |
DE-627 |
| 005 |
20250217131024.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1111/vcp.12201
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0807.xml
|
| 035 |
|
|
|a (DE-627)NLM242173853
|
| 035 |
|
|
|a (NLM)25250671
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Lygren, Tone
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Serum insulin-like growth factor 1 in the aging horse
|
| 264 |
|
1 |
|c 2014
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 20.11.2015
|
| 500 |
|
|
|a Date Revised 20.10.2016
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2014 American Society for Veterinary Clinical Pathology.
|
| 520 |
|
|
|a BACKGROUND: Insulin-like growth factor 1 (IGF-1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses
|
| 520 |
|
|
|a OBJECTIVES: The objective of this study was to determine serum IGF-1 levels in the aging horse from early to late adulthood (age range 5-27 years)
|
| 520 |
|
|
|a METHODS: Healthy horses (n = 72) were used in a cross-sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF-1 protein was determined using an ELISA kit validated for use in equine samples
|
| 520 |
|
|
|a RESULTS: No association was found between serum IGF-1 levels and age in the cross-sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF-1 levels over a 5-year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease
|
| 520 |
|
|
|a CONCLUSIONS: In this study, there was no evidence for aging being a factor in changes of IGF-1 levels in an adult and old horse population
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a ELISA
|
| 650 |
|
4 |
|a equine
|
| 650 |
|
4 |
|a growth factors
|
| 650 |
|
4 |
|a longitudinal study
|
| 650 |
|
4 |
|a senescence
|
| 650 |
|
7 |
|a Insulin-Like Growth Factor I
|2 NLM
|
| 650 |
|
7 |
|a 67763-96-6
|2 NLM
|
| 700 |
1 |
|
|a Hansen, Sanni
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Langberg, Henning
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Fjeldborg, Julie
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jacobsen, Stine
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Nielsen, Mette O
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Schjerling, Peter
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Markussen, Bo
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Thomsen, Preben D
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Berg, Lise C
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 43(2014), 4 vom: 03. Dez., Seite 557-60
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
|
| 773 |
1 |
8 |
|g volume:43
|g year:2014
|g number:4
|g day:03
|g month:12
|g pages:557-60
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/vcp.12201
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 43
|j 2014
|e 4
|b 03
|c 12
|h 557-60
|